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Iranian Journal of Microbiology، جلد ۱۴، شماره ۳، صفحات ۲۷۶-۲۸۴
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عنوان انگلیسی Candida auris: outbreak fungal pathogen in COVID-19 pandemic: a systematic review and meta-analysis
چکیده انگلیسی مقاله Background and Objectives: Candida auris (C. auris) is the first fungal pathogen considered a global health threat. Because, C. auris is associated with multidrug resistance and associated diseases such as diabetes, sepsis, lung and kidney disease. This study investigated the prevalence and mortality of C. auris infection during Covid-19 pandemic. Materials and Methods: Databases were searched for peer-reviewed articles published in the English language up to Jan 18, 2022. Heterogeneity across studies was evaluated using Cochrane’s Q test and the I2 index. The pooled point prevalences and their corresponding 95% confidence intervals (CIs) were estimated usingthe random-effects model. Results: In our meta-analysis, 11 eligible articles were included. The total pooled prevalence estimation of C. auris infection among COVID-19 patients was 13% (95% CI: 8%, 19%). The estimated pooled mortality rate of C. auris infection was 37% (95% CI: 15%, 61%). In terms of specific conditions, the pooled risk of mortality was higher in people with diabetes 65% (95% CI: 0.45%, 83%), in cases with >21 days admission inintensive care unit (ICU) 44% (95% CI: 21%, 0.68%), and after receiving steroids 43% (95% CI: 18%, 69%). Conclusion: Our study highlights the high prevalence rate of C. auris infection, particularly among people with a history of metabolic disorders.
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نویسندگان مقاله | Kamran Lankarani
Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran


| Maryam Akbari
Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran


| Reza Tabrizi
Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran; Clinical Research Development Unit of Vali Asr Hospital, Fasa University of Medical Sciences, Fasa, Iran


| Mohebat Vali
Department of Epidemiology, Shiraz University of Medical Sciences, Shiraz, Iran


| Eghbal Sekhavati
Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran


| Seyed Taghi Heydari
Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran


| Hossein Khodadadi
Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran


| Fariba Ahmadizar
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/3355
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