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Middle East Journal of Digestive Diseases، جلد ۱۴، شماره ۲، صفحات ۱۸۲-۱۹۱
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عنوان انگلیسی Susceptibility of Patients with Inflammatory Bowel Disease to COVID-19 Compared with Their Households
چکیده انگلیسی مقاله BACKGROUND: Immunosuppressive agents used in the treatment of inflammatory bowel diseases (IBD) could potentially increase the risk of COVID-19 (Coronavirus disease 2019). We aimed to compare COVID-19 frequency in patients with IBD with their households and identify the related risk factors. METHODS: Firstly, a multi-centered, observational study on 2,110 patients with IBD and 2110 age-matched household members was conducted to compare COVID-19 frequency. Secondly, the data of patients with IBD and COVID-19 who had called the COVID-19 hotline were added. Multivariable logistic regression was used to evaluate the effect of age, type and severity of IBD, the number of comorbidities, and medications on the frequency of COVID-19 among the patients with IBD. RESULTS: The prevalence of COVID-19 in patients with IBD and household groups was similar [34 (1.61%) versus 35 (1.65%) ( p = 0.995)]. The prevalence of COVID-19 increased from 2.1% to 7.1% in those with three or more comorbidities ( p = 0.015) and it was significantly higher in those with severe IBD ( p = 0.026). The multivariable analysis only showed a significant association with anti-TNF monotherapy (OR:2.5, CI: 0.97-6.71, p = 0.05), and other medications were not associated with COVID-19. CONCLUSIONS: The prevalence of COVID-19 in patients with IBD was similar to the household members. Only patients with IBD receiving anti-TNF monotherapy had a higher risk of COVID-19 susceptibility. This finding could be attributed to the higher exposure to the virus during administration in health care facilities.
کلیدواژه‌های انگلیسی مقاله Inflammatory bowel disease,COVID-19,Medications,Frequency
نویسندگان مقاله | Amir Anushiravani
Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran


| Bahar Saberzadeh-Ardestani
Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran


| Homayoon Vahedi
Gut and Liver Research Center, Mazandaran University of Medical Sciences, Sari, Iran


| Hafez Fakheri
Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran


| Fariborz Mansour-Ghanaei
Gut and Liver Research Center, Mazandaran University of Medical Sciences, Sari, Iran


| Iradj Maleki
Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran


| Siavosh Nasseri-Moghaddam
Gastroenterology and Hematology Department, Faculty of Medicine, Ghaem Hospital, Mashhad, Iran


| Hasan Vosoghinia
Gastroenterology and Hepatology Diseases Research Center, Qom University of Medical Science, Iran


| Mohammad Reza Ghadir
Gastroenterology and Hepatology Diseases Research Center, Qom University of Medical Science, Iran Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran


| Ahmad Hormati
Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran


| Amir Kasaeian
Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran


| Amir Reza Radmard
Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran


| Bardia Khosravi
Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran


| Masoud Malekzadeh
Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran


| Sudabeh Alatab
Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran


| Anahita Sadeghi
Department of Epidemiology and Statistics, Faculty of Health Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran


| Nayyereh Aminisani
Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran


| Hossein Poustchi
Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran


| Ali Reza sima
Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran


| Reza Malekzadeh


نشانی اینترنتی http://mejdd.org/index.php/mejdd/article/view/2497
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