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Physiology and Pharmacology، جلد ۲۶، شماره ۲، صفحات ۱۲۷-۱۳۷
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عنوان انگلیسی Enriched environment restores passive avoidance memory impairment in a rat model of neuroinflammation
چکیده انگلیسی مقاله Introduction: Neuroinflammation is a primary pathophysiological condition that is associated with cognitive impairment and neurodegenerative diseases. The present study was designed to evaluate the effects of enriched environment (EE) on passive avoidance (PA) memory impairment caused by lipopolysaccharide (LPS) induced neuroinflammation. Methods: Twenty-eight male Wistar rats were assigned into the following groups: 1, control; 2, control+ EE; 3, LPS and 4, LPS+ EE. LPS injection (1mg/kg/i.p.) was done on days 1, 3, 5 and 7 of experiment. Two different housing conditions were used in this experiment, including a standard environment house and an enriched environment house. The passive avoidance task was used to examine animals learning and memory performance. The hippocampal level of interleukin-6 (IL-6) and brain-derived neurotrophic factor (BDNF) was also measured using sandwich-ELISA method. Results: Obtained data indicated that LPS significantly impaired passive avoidance memory, decreased the step-through latency and increased the time spent in the dark compartment of the LPS treated group compared to the control group. On the other hand, EE housing could significantly ameliorate memory impairment. Hippocampal IL-6 level was increased and BDNF was decreased in the LPS group, whereas EE could decrease and increase IL-6 and BDNF levels in the LPS+EE group, respectively. Conclusion: EE should probably be considered as an alternative strategy in neuroinflammatory diseases to minimize the memory impairment.
کلیدواژه‌های انگلیسی مقاله Inflammation, Enriched environment, Memory, Passive avoidance
نویسندگان مقاله | Arman Keymoradzadeh
Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran


| Mojtaba Hedayati Ch
Department of Microbiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran


| Mahmood Abedinzade
Medical Biotechnology Research Center, School of Nursing, Midwifery and Paramedicine, Guilan University of Medical Sciences, Rasht, Iran


| Behrooz Khakpour-Taleghani
Neuroscience Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-10-1586-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Blood and Immune System
نوع مقاله منتشر شده Experimental research article
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