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Physiology and Pharmacology، جلد ۲۶، شماره ۲، صفحات ۱۶۸-۱۷۷
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عنوان انگلیسی Time course of renal ischemia/reperfusion and distance organ: lung dysfunction in male and female rats
چکیده انگلیسی مقاله Introduction: Renal ischemia/reperfusion injury (IRI) may influence distance organ such as lung. The severity of IRI induced- lung insult can be affected by gender and reperfusion time alteration. The aim of this study was to determine gender differences in renal IR inducedlung injury in different reperfusion time. Methods: Eighty male and female rats were assigned into 8 groups, 4 groups in each gender including: sham, renal ischemia for 45min by clamping renal vessels followed by 3, 24 or 48h reperfusion. Blood samples were obtained for measuring the serum level of blood urea nitrogen (BUN), creatinine (Cr), nitrite and malondialdehyde (MDA). The kidneys and lung tissues were removed and used for MDA and nitrite measurements and the histological changes evaluation. The lung water content was calculated. Results: In both genders, the rise in Cr and BUN reached the peak at 24h reperfusion. A significant increment was seen in female serum level of nitrite compared with males after 3h reperfusion. The renal MDA level of male increased during 3h reperfusion but not seen in females. The enhanced lung and renal tissues damages were depended to reperfusion time in both genders. The water content of lung was reduced in 3h of reperfusion groups. Conclusion: Sex effects and the time of reperfusion may be the important factors to consider clinical therapeutic of renal IRI as well as its impact on remote organs.
کلیدواژه‌های انگلیسی مقاله Renal ischemia-reperfusion, Lung, Gender, Distant organ
نویسندگان مقاله | Fariba Azarkish
Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran


| Ali Atash Ab Parvar
Department of Pathology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran


| Mehdi Nematbakhsh
Water and Electrolytes Research Center/Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran


| Aghdas Dehghani
Endocrinology and Metabolism Research Center/Department of Physiology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-10-1485-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Renal Physiology/Pharmacology
نوع مقاله منتشر شده Experimental research article
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