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Iranian Journal of Public Health، جلد ۵۱، شماره ۷، صفحات ۱۵۰۲-۱۵۱۲
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عنوان انگلیسی Economic Evaluation of Denosumab for Treatment of Postmenopausal Osteoporosis: A Systematic Review
چکیده انگلیسی مقاله Background: We aimed to review the systematic economic evaluation of denosumab versus than alternative drugs and oral bisphosphonates of postmenopausal osteoporosis in women and help health system policy makers for prioritizing and optimally allocate limited health resources. Methods: We examined the databases of PubMed, Web of Science, Embase, Scopus, Cochrane Library, ProQuest. Strategy search was designed based on keywords. Inclusion criteria were: studies that conducted economic evaluation denosumab compared to oral bisphosphonates for the treatment of osteoporosis in postmenopausal women. Cost-effectiveness studies conducted using decision analysis models based on the economic evaluation approach; studies with available full-text papers; and studies written in English and published between 2010 and 2020. After selecting articles based on inclusion and exclusion criteria, data were extracted and the results were summarized. The quality of the articles was evaluated using the CHEERS checklist. Results: Among 214 initial studies, 8 studies met the inclusion criteria. Most studies focused on the cost-effectiveness of denosumab compared with oral bisphosphonates for the treatment of osteoporosis. The study agreed interval ranged from 3 months to 5 years. The costs investigated in the studies were direct medical costs. In most studies, the use of denosumab significantly prevented fractures. Conclusion: Denosumab is generally more cost-effective than alternative drugs and oral bisphosphonates (alendronate, risedronate, strontium ranelate, ibandronate, and untreated).  
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نویسندگان مقاله | Shahin Nargesi
Department of Public Health, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran


| Saeed Husseini Barghazan
Department of Health Economic, School of Health Management and Information Sciences, Iran University of Medical Sciences, Teh-ran, Iran


| Nadia Sani'ee
Department of Medical Library and Information Sciences, Student Research Committee, Iran University of Medical Sciences, Tehran, Iran


| Asma Rashki Kemmak
Department of Health Economic, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/24562
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