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Research in Pharmaceutical Sciences، جلد ۱۷، شماره ۴، صفحات ۴۱۰-۴۱۶
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عنوان انگلیسی Antihyperglycemic and hepatoprotective effects of Salvia tebesana Bunge in diabetic rats
چکیده انگلیسی مقاله Background and purpose: Medicinal plants have been used to cure numerous diseases compared to orthodox medicines. The present study estimated the antidiabetic activity of ethanolic extract of Salvia tebesana Bunge in streptozotocin-induced diabetic rats. Experimental approach: In this study type 2 diabetes was induced in male rats by streptozotocin (65 mg/kg, i.p.). After diabetes induction, normal control groups were treated with distilled water, the positive control group received metformin (500 mg/kg), and the other groups were orally treated with ethanolic extracts of S. tebesana (100, 200, and 400 mg/kg) for 4 weeks. Changes in body weight and some biochemical parameters were determined. Findings / Results: The ethanolic extract of S. tebesana in all doses considerably declined serum glucose, total cholesterol, alanine aminotransferase, aspartate aminotransferase, and triglyceride compared with the diabetic control rats. Administration of ethanolic extract of S. tebesana reduced the serum of kidney and liver function factors and decreased the side effects on the function of these. Conclusion and implications: These results revealed the potential of S. tebesana for the cure of diabetes and its problems.
کلیدواژه‌های انگلیسی مقاله Keywords, Diabetic rat,Metformin,Salvia tebesana Bunge,Streptozotocin.
نویسندگان مقاله | Hamed Aramjoo
2Department of Pharmacology, School of Pharmacy, Birjand University of Medical Sciences, Birjand, I.R. Iran. 3Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, I.R. Iran.


| Zahra Kiani
3Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, I.R. Iran. 4Department of Pharmacognosy and Traditional Pharmacy, School of Pharmacy, Birjand University of Medical Sciences, Birjand, I.R. Iran.


| Samira Eghbali


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2137
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