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Journal of Medical Signals and Sensors، جلد ۱۲، شماره ۳، صفحات ۲۰۲-۲۱۸
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عنوان انگلیسی Predicting efficacy of 5-fluorouracil therapy via a mathematical model with fuzzy uncertain parameters
چکیده انگلیسی مقاله Background: Due to imprecise/missing data used for parameterization of ordinary differential equations (ODEs), model parameters are uncertain. Uncertainty of parameters has hindered the application of ODEs that require accurate parameters. Methods: We extended an available ODE model of tumor-immune system interactions via fuzzy logic to illustrate the fuzzification procedure of an ODE model. The fuzzy ODE (FODE) model assigns a fuzzy number to the parameters, to capture parametric uncertainty. We used the FODE model to predict tumor and immune cell dynamics and to assess the efficacy of 5-fluorouracil (5-FU) chemotherapy. Result: FODE model investigates how parametric uncertainty affects the uncertainty band of cell dynamics in the presence and absence of 5-FU treatment. In silico experiments revealed that the frequent 5-FU injection created a beneficial tumor microenvironment that exerted detrimental effects on tumor cells by enhancing the infiltration of CD8+ T cells, and natural killer cells, and decreasing that of myeloid-derived suppressor cells. The global sensitivity analysis was proved model robustness against random perturbation to parameters. Conclusion: ODE models with fuzzy uncertain kinetic parameters cope with insufficient/imprecise experimental data in the field of mathematical oncology and can predict cell dynamics uncertainty band.
کلیدواژه‌های انگلیسی مقاله 5-fluorouracil, fuzzy, ordinary differential equation, uncertain
نویسندگان مقاله | Sajad Shafiekhani
Departments of Biomedical Engineering, Research Center for Biomedical Technologies and Robotics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Amir Homayoun Jafari
Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Leila Jafarzadeh
Department of Biomedical Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


| Vahid Sadeghi
Department of Medical Biotechnology, School of Paramedical Sciences; Cellular and Molecular Research Center, Research Institute for Prevention of Noncommunicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran


| Nematollah Gheibi


نشانی اینترنتی http://jmss.mui.ac.ir/index.php/jmss/article/view/623
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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