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Journal of Research in Medical Sciences، جلد ۲۷، شماره ۱۶، صفحات ۲۰۲۲-۲۷
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عنوان انگلیسی Evaluation of the prognostic value of neutrophil to lymphocyte ratio and platelet?to?lymphocyte ratio in acute exacerbation of chronic obstructive pulmonary disease
چکیده انگلیسی مقاله Background: The present study aimed at determining and comparing the prognostic value and the relationship of neutrophil?to?lymphocyte and platelet?to?lymphocyte ratios (PLRs) with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Materials and Methods: The present case–control study was performed on 100 chronic obstructive pulmonary disease patients and 100 healthy subjects (controls). Age, ender, and laboratory results of complete blood count tests including lymphocyte count, neutrophil count, platelet count, hemoglobin level, eutrophil?to?lymphocyte ratio (NLR), PLR, C?reactive protein (CRP), and rythrocyte sedimentation rate (ESR) were obtained from the patient report nd then recorded. The mentioned information was also completed for the control group. Following hospitalization, the patients that were discharged ith clinically stable general status were re?examined, and the forementioned laboratory information was rerecorded. Results: The results f the present study revealed that NLR with the sensitivity and specificity of 3.00% (74.2%–89.8%) and 93.00% (86.1%–97.1%) (cutoff value of 2.3), PLR with the sensitivity and specificity of 56.00% (46.0%–66.3%) and 3.00% (74.2%–89.8%) (cutoff value of 135.8), white blood cell (WBC) with he sensitivity and specificity of 69.00% (57.7%–77.8%) and 78.00% 68.6%–85.7%) (cutoff value of 8.5 × 103 ?l), ESR with the sensitivity and specificity of 84.00% (75.3%–90.6%) and 99.00% (94.6%–100.0%) (cutoff alue of 7.8), and CRP with the sensitivity and specificity of 52.00% (41.8%–62.1%) and 81.00% (71.9%–88.2%) (cutoff value of 1.9), respectively, had a significant prognostic value of AECOPD (P < 0.001). In addition to NLR ad higher area under the curve (AUC) than PLR, WBC, and CRP. Therefore LR had a better diagnostic value than the above three markers (P < 0.001). ESR also has higher AUC levels compared to PLR, WBC, and CRP nd has a statistically better diagnostic value than them (P < 0.001), but did ot differ significantly from ESR (difference between AUC: 0.02; P = .059). Conclusion: According to the results of the current study, NLR and LR had a significant direct relationship with the two main markers of ESR and CRP, and both ratios had a significant prognostic value in AECOPD.
کلیدواژه‌های انگلیسی مقاله Blood platelets, chronic obstructive pulmonary disease, lymphocytes, neutrophils Address for
نویسندگان مقاله | Mohammad Emami Ardestani


| Nooshin Alavi Naeini


نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/11361
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