| چکیده انگلیسی مقاله |
Background
Coronary heart disease (CHD) is the leading cause of morbidity and mortality globally, and specifically in Iran. Accurate assessments of Coronary heart disease (CHD) incidence is very necessary for public health. In current study we aimed to investigate the incidence of CHD and
importance of several classical, modifiable and un-modifiable risk factors for CHD among an urban population in eastern Iran after 6 years of follow-up.
Methods
The population of MASHAD cohort study were followed up for 6 years, every 3 years in two step by phone and who reported symptoms of CVD were asked to attend for a cardiac examination, to estimate the incidence of CHD with 95% confidence interval (95% CI) as well multiple logistic regression analysis was performed to assess the association of several baseline characteristics with incidence of CHD event. Evaluation of goodness-of-fit was done using ROC analysis. CHD cases divided into four different classes which include: stable angina, unstable angina pectoris, myocardial infarction and sudden cardiac death.
Results
In the six years' follow-up of Mashhad study, the incidence rate of all CHD event in men and women in 100,000 people-years with 95% confidence intervals were 1920 (810-3030) and 1160 (730-1590), respectively. The areas under ROC curve (AUC), based on multivariate predictors of CHD outcome, was 0.7825.
Conclusion
Our findings indicated that the incidence rate of coronary heart diseases in MASHAD cohort study increases with age as well as our final model designed, was able to predict approximately 78% of CHD events in Iranian population.
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| نویسندگان مقاله |
| majid Ghayour-Mobarhan
10. International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
| Fatemeh Sadabadi
Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
| Mohsen Moohebati
Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
| Alireza Heidari-Bakavoli
Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran. Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Sousan Darroudi
Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
| Shahin Nazarpour
Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
| Mohammad Sadegh Khorrami Mohebbseraj
3. Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;
| Zahra Asadi
Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
| Habibollah Esmaeily
4. Department of Biostatistics & Epidemiology, School of Health, Management & Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
| Hamideh Ghazizadeh
Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
| Elham Barati
Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
| Najmeh malekzadeh Gonabadi
Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
| Sara Samadi
Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
| Maryam Tayefi
Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
| Zahra Izadi mood
Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
| Mahmoud Reza Azarpazhooh
Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
| Sahar Heidari- Bakavoli
Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
| Tara Hoori
Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
| Ramin Bahramizadeh Sajjadi
Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
| Gordon Ferns
9. Department of Medical Education, Brighton & Sussex Medical School, Brighton, BN1 9PH, UK
| Hamid Heidarian Miri
Department of Biostatistics & Epidemiology, School of Health, Management & Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
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