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Iranian Journal of Microbiology، جلد ۱۴، شماره ۴، صفحات ۴۴۵-۴۵۷
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عنوان انگلیسی Phylogenetic groups, serogroups and virulence factors of uropathogenic Escherichia coli isolated from patients with urinary tract infection in Baghdad, Iraq
چکیده انگلیسی مقاله Background and Objectives: Uropathogenic Escherichia coli (UPEC) is divided into different phylogenetic groups that differ in their antibiotic resistance patterns, serogroups and pathogenicity. This study aimed to investigate the prevalence of phylogenetic groups of UPEC isolates and their relationship with serogroups and virulence factors in patients with UTIs. Materials and Methods: Of the 412 urine samples tested a total of 150 UPEC were isolated and confirmed with PCR using 16S rRNA gene. Antibiotic resistance of the isolates was tested using disk diffusion method and the isolates were divided into phylogenetic groups by the quadruplex PCR method. The prevalence of serogroups and virulence genes were investigated using multiplex PCR. Results: 87 (58%) of the isolates belonged to phylogroup B2. Virulence genes fimH (95.3%), aer (49.3%) and serogroups O8 (22.3%), O25 (21.5%) showed the highest prevalence. The lowest drug resistance was observed against imipenem (4.6%) and meropenem (3.3%). The prevalence of multidrug-resistant and extended-spectrum beta-lactamases isolates were 60% and 61.3%, respectively. We also found a significant relationship between phylogenetic groups, serogroups and virulence factors among our isolates. Conclusion: The high abundance of phylogenetic group B2, serogroups O8 and O25, and virulence genes fimH and aer indicate their importance in the pathogenesis of UPEC in this country.
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نویسندگان مقاله | Eman Mohammed
Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq


| Kadhim Hasan
Department of Surgery, Babil Medical College, University of Babylon, Babil, Iraq


| Mohammed Allami
Department of Dentistry, Al-Manara College for Medical Sciences, Maysan, Iraq; Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/3513
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