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Acta Medica Iranica، جلد ۶۰، شماره ۷، صفحات ۴۱۳-۴۱۷
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عنوان انگلیسی Dexamethasone Treatment in Patients With Severe COVID-19: A Propensity Score-Matched Study
چکیده انگلیسی مقاله During the coronavirus disease-2019 (COVID-19) pandemic, which was caused by the novel coronavirus, there is an ongoing controversy about the use of corticosteroids. This study aims to investigate the association between Dexamethasone treatment and clinical outcomes in patients with severe COVID-19. In this single-center retrospective cohort study, patients with COVID-19 were enrolled from February 16, 2020, to November 1, 2020. After performing propensity score matching with age, sex, and disease severity. The independent effect of Dexamethasone treatment on in-hospital mortality was evaluated by multivariate proportional hazards regression models. Of 1413 patients with COVID-19 diagnosis, 1172 patients entered the final analysis. 473(40.4%) patients received dexamethasone treatment with a median duration of 6.0[4.0-9.0] days. After matching and adjustment with possible confounders in the multivariate model, administration of dexamethasone significantly increased the survival in severe patients (hazard ratio: 0.25, 95 confidence intervals: 0.16-0.38, P< 0.001), but there was no difference in non-severe patients (P:0.888). The administering of dexamethasone was associated with an increased in-hospital survival rate (HR: 0.25 [0.16-0.38]) in severe COVID-19 patients. The survival rate was more significant in severe patients with diabetes mellitus or hypertension after receiving dexamethasone treatment (HR:0.19). On the other hand, patients without severe disease did not benefit from dexamethasone administration.
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نویسندگان مقاله | Mahnaz Montazeri
Department of Infectious Diseases, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran


| Marzieh Pazoki
Department of Pulmonary Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran


| Azar Hadadi
Department of Infectious Diseases, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran


| Melika Shafeghat
Students&apos; Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran


| Abdolazim Veisizadeh
Department of Infectious Diseases, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran


| Mohammad Reza Khajavi
Department of Anesthesiology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran


| Farhad Najmeddin
Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran


| Samira Kafan
Department of Pulmonary Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://acta.tums.ac.ir/index.php/acta/article/view/9967
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