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Middle East Journal of Digestive Diseases، جلد ۱۴، شماره ۳، صفحات ۳۳۵-۳۳۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Systematic Review and Meta-analysis of TP53, HER2/ERBB2, KRAS, APC, and PIK3CA Genes Expression Pattern in Gastric Cancer |
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| چکیده انگلیسی مقاله |
BACKGROUND: With a global prevalence of about 10%, gastric cancer is among the most prevalent cancers. Currently, there has been an ongoing trend toward investigating genetic disruptions in different cancers because they can be used as a target-specific therapy. We aimed to systemically review some gene expression patterns in gastric cancer. METHODS: The current systematic review was designed and executed in 2020. Scopus, PubMed, Cochrane Library, Google Scholar, web of knowledge, and Science Direct were searched for relevant studies. A manual search of articles (hand searching), reference exploring, checking for grey literature, and seeking expert opinion were also done. RESULTS: In this review, 65 studies were included, and the expression pattern of HER2/ERBB2, ER1/Erb1/EGFR, PIK3CA, APC, KRAS, ARID1A, TP53, FGFR2 and MET was investigated. TP53, APC, KRAS, and PIK3CA mutation cumulative frequency were 24.8 (I 2 =95.05, Q value=525.53, df=26, P < 0.001), 7.2 (I 2 = 89.79, Q value = 48.99, df = 5, P < 0.001), 7.8 (I 2 = 93.60, Q value = 140.71, df = 9, P = 0.001) and 8.6 (I 2 = 80.78, Q value = 525.53, df = 9, P < 0.001) percent, respectively. Overexpression was investigated for HER1/Erb1/EGFR, PIK3CA, APC, KRAS, ARID1A, TP53, CCND1, FGFR2, MET and MYC. The frequency of TP53 and HER2/ERBB2 were 43.1 (I 2 = 84.06, Q value = 58.09, df = 9, P < 0.001) and 20.8 (I 2 = 93.61, Q value = 234.89, df = 15, P < 0.001) percent, respectively. CONCLUSION: More research is encouraged to investigate the genes for which we could not perform a meta-analysis. |
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| کلیدواژههای انگلیسی مقاله |
Gastric cancer,Over expression,systematic review |
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| نویسندگان مقاله |
| Morteza Ghojazadeh
Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
| Mohammad Hossein Somi
1. Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
2. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
| Amirreza Naseri
Research Center for Evidence-based medicine, Iranian EBM Centre: A Joanna Briggs Institute (JBI) Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran.
| Hanieh Salehi-Pourmehr
Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
| Zeinab Nikniaz
1.Research Center for Evidence-based medicine, Iranian EBM Centre: A Joanna Briggs Institute (JBI) Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran.
2. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
| Sina Hassannezhad
-Research Center for Evidence-based medicine, Iranian EBM Centre: A Joanna Briggs Institute (JBI) Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran.
- Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
| Arash Hajikamanaj Olia
Genetic Department, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
| Leila Kafshdouz
Hematology & Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
| Hadi Chavoshi
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| نشانی اینترنتی |
http://mejdd.org/index.php/mejdd/article/view/2400 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Systematic Review |
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