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Physiology and Pharmacology، جلد ۲۶، شماره ۳، صفحات ۲۹۹-۳۱۲
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عنوان انگلیسی Fresh palm oil improves impaired renal function in phenylhydrazine-induced anaemic Wistar rats via its anti-anaemic effect and modulation of expressions of pro-oxidant/antioxidants, inflammatory cytokines and caspase-3 in the kidneys
چکیده انگلیسی مقاله Introduction: Phenylhydrazine (PHZ)-induced anaemia is associated with oxidative damage to erythrocytes and impaired renal function. Fresh palm oil (FPO) is a rich source of antioxidants and preserves renal function. This study investigated the possible reno-protective effects of FPO in PHZ-induced anaemic Wistar rats. Methods: Eighteen male Wistar rats were randomly assigned into normal control (NC), anaemic control (AC; 60mg/kg of PHZ) and anaemic treated (A+FPO; 60mg/kg of PHZ + 15% FPO diet) groups. PHZ was administered twice consecutively at 48h interval while FPO diet was given throughout the study period (14 days). Results: Erythrocyte count, haemoglobin concentration and haematocrit were increased in A+FPO compared with AC. FPO improved imbalances in the levels of glucose and electrolytes (Na+, Cl-, K+, HCO3-) in serum and urine of the anaemic rats. Urea and creatinine concentrations were decreased in serum and increased in urine in the A+FPO relative to AC. Proteinuria was decreased in A+FPO compared with AC. The levels of malondialdehyde, proinflammatory cytokines and caspase-3 were down-regulated in A+FPO compared with AC while interleukin-10 concentration, enzymatic antioxidants activities and total antioxidant capacity were up-regulated in A+FPO compared with AC. Conclusion: FPO demonstrated anti-anaemic effect and improved the impaired renal function associated with PHZ-induced anaemia.
کلیدواژه‌های انگلیسی مقاله Anaemia, Fresh palm oil, Haemolysis, Phenylhydrazine, Renal function
نویسندگان مقاله | Ernest Atelhe Amama
Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Nigeria


| Augustine Lishilinimye Udefa
Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Nigeria


| Favour Nyoh Beshel
Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Nigeria


| Efiok Aniekan Archibong
Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Nigeria


| Sunday Okpa
Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Nigeria


| Justina Nwandimma Nwangwa
Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Nigeria


| Ndianabasi Isidore Felix
Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Nigeria


| Godwin Akronyi
Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Nigeria
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-10-1447-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Renal Physiology/Pharmacology
نوع مقاله منتشر شده Experimental research article
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