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Physiology and Pharmacology، جلد ۲۶، شماره ۳، صفحات ۳۱۳-۳۲۱
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عنوان انگلیسی The effect of ellagic acid on renal injury associated with acrylamide in experimental rats
چکیده انگلیسی مقاله Introduction: Acrylamide (ACR) is a toxic substance that has renal toxicity. We aim to investigate the therapeutic activity of ellagic acid (EA) on renal injury induced by ACR in Wistar rats. Methods: Thirty-five male Wistar rats were assigned into 5 groups: the control group (5ml/kg normal saline), the ACR group (20mg/kg ACR), the ACR+EA10 group (ACR and 10mg/kg EA), the ACR+EA30 group (ACR and 30mg/kg EA) and the EA30 group (30mg/kg EA). ACR and EA were daily administered by gavage for 30 days. Renal function was assessed by measuring the sera levels of creatinine (Cr) and blood urea nitrogen (BUN). Renal oxidative and inflammatory markers including malondialdehyde (MDA), nitric oxide (NO), protein carbonyl (PC), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). hematoxylin and eosin staining was employed to assess pathological alternations of the kidney. Results: EA (more potentially 30mg/kg) administration alleviated the ACR-induced alterations in Cr and BUN levels. Moreover, EA treatment reduced the elevated levels of MDA, NO and PC as well as TNF-α and IL-1β content in renal tissue. Furthermore, reduced activity of SOD and CAT as well as GSH content in the kidney was increased by EA treatment. EA attenuated the ACR- induced pathological alterations in kidney. Conclusion: These findings suggested that EA could mitigate ACR-induced kidney injury due to its potent antioxidant and anti-inflammatory effects.
کلیدواژه‌های انگلیسی مقاله Acrylamide, Oxidative stress, Inflammation, Nephrotoxicity, Ellagic acid
نویسندگان مقاله | Saeed Mehrzadi
Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran


| Mohammad Amin Mombeini
Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Iman Fatemi
Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran


| Heibatullah Kalantari
Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Mojtaba Kalantar
Shoushtar Faculty of Medical Sciences, Shoushtar, Iran


| Mehdi Goudarzi
Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-10-873-3&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Toxicology
نوع مقاله منتشر شده Experimental research article
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