این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Physiology and Pharmacology، جلد ۲۶، شماره ۳، صفحات ۳۳۳-۳۴۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Preventive effects of microvesicles isolated from Bifidobacterium bifidum on 4T1-induced breast cancer in BALB/c mice
چکیده انگلیسی مقاله Introduction: Breast cancer is one of the important causes of mortality among women. Many studies have focused on the development of natural health products for prevention and treatment of breast cancer. This study investigated the effects of Bifidobacterium bifidum and its microvesicles (MVs) on 4T1-induced breast cancer in BALB/c mice. Methods: Sixty female BALB/c mice were divided into 5 groups: (1) negative control, (2) positive control, (3) doxorubicin, (4) probiotic and (5) MVs (isolated from B. bifidum). The mice in groups 4 and 5 were pretreated with B. bifidum and MVs for 4 weeks, respectively. Tumor was induced by subcutaneous administration of 4T1 cell culture. After tumor development, mice in group 3 were treated with doxorubicin while other groups were treated as before. The mice were sacrificed after 3 weeks, breast tumors were removed and histologically examined. Also, P53 and Ki67 protein were evaluated by immunohistochemistry staining, and P53 gene expression was assessed by RT-PCR. Results: Pretreatment with MVs and probiotic reduced mortality and tumor growth rate. MVs and Probiotic prevented the weight loss and suppressed tumor cell proliferation which was indicated by Ki-67 and p53. The expression of p53 confirmed these results. Despite the malignancy in the breast tissue, necrosis of cancer cells occurred in the mice treated with MVs. Conclusion: MVs of B. bifidum effectively inhibited breast cancer development in mice and suppressed tumor cell proliferation. Probiotic microorganisms and their metabolites can be used as a functional food to prevent breast cancer.
کلیدواژه‌های انگلیسی مقاله Triple negative breast cancer, Probiotic, Bifidobacterium bifidum, Microvesicles, Ki67, p53
نویسندگان مقاله | Farzanrh Nazari
Microbiology Department, Science Faculty, Islamic Azad University , Arak Branch, Arak, Iran


| Parvaneh Jafari
Microbiology Department, Science Faculty, Islamic Azad University , Arak Branch, Arak, Iran


| Bizhan Nomanpour
School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Kamibiz Varmira
Research Center of Oils and Fats, Kermanshah University of Medical sciences, Kermanshah, Iran


| Farshid Reissi
School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-10-1421-1&slc_lang=en&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Blood and Immune System
نوع مقاله منتشر شده Experimental research article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات