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Journal of Research in Medical Sciences، جلد ۲۷، شماره ۱۸، صفحات ۲۰۲۲-۲۷
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عنوان انگلیسی Electrophysiological and therapeutic effects of amiodarone in patients with preexcited atrial fibrillation
چکیده انگلیسی مقاله Background: Atrial fibrillation (AF) with fast ventricular response over an overt accessory pathway (AP) (preexcited AF) with a short anterograde refractory period is a potentially malignant arrhythmia. This study aimed to evaluate the safety and efficacy of amiodarone for preexcited AF management. Materials and Methods: This study enrolled 103 patients with evidence of AP in electrocardiography. Patients with preexcited AF were included in the study. Intravenous amiodarone (300 mg) was nfused for 30 min for all patients in the AF rhythm. Electrophysiological parameters were evaluated before amiodarone injection and 2 h after pharmacological or electrical cardioversion. Results: Antegrade and retrograde refractory periods of the atrioventricular node (AVN) and AP, as well as antegrade and retrograde Wenckebach points of AVN, were increased significantly after amiodarone infusion. Furthermore, the mean of the shortest preexcited RR interval was increased during the onitoring period. Comparing the preexcited index at the beginning of the study and before cardioversion (2 h later) revealed that the QRS complexes anged to a wider pattern as the preexcitation index changed from 80.61 to 92.26 (P < 0.001). Nineteen (18.4%) patients converted to the sinus rhythm with amiodarone infusion. No ventricular arrhythmia was detected during monitoring. Conclusion: Amiodarone could be considered a safe drug in patients with preexcited AF for rate control despite its relatively low efficacy in conversion to the sinus rhythm.
کلیدواژه‌های انگلیسی مقاله Accessory pathway, amiodarone, atrial fibrillation, electrophysiology
نویسندگان مقاله | Abolfath Alizadeh


| Maryam Pakroo


| Shabnam Madadi


| Ala Keikhavani


| Zahra Teimouri Jervekani


| Behshid Ghadrdoost


| Zahra Emkanjoo


نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/11373
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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