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International Journal of Radiation Research، جلد ۲۰، شماره ۴، صفحات ۷۹۳-۷۹۸
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عنوان انگلیسی Intratumoral injection of radioactive Astatine (211At) microspheres for the treatment of tumors
چکیده انگلیسی مقاله Background: Our aims were to prepare microspheres labelled with radioactive astatine as brachytherapy seeds and to confirm the antitumor ability of these microspheres. Materials and Methods: Chitosan-collagen composite microspheres (CCMs) were synthesized through an emulsification crosslink reaction and radiolabelled with 211At using the chloramine-T method. Radiation stability was assessed in both phosphate-buffered saline and blood serum. The in vivo distribution and therapeutic effects were evaluated in BALB/c nude mice with implanted tumours. Results: CCMs showed ideal morphological characteristics (diameter of 7.5-15 μm) and acceptable radiation stability (73.99% in PBS and 72.56% in serum after 16 hours). The in vivo biodistribution analysis demonstrated that 211At-CCMs were highly localized in tumour tissue. The therapeutic efficacy of 211At-CCMs when intratumorally injected into a cervical tumour model was assessed. Fourteen days after a single-dose treatment with 211At-CCMs, significantly retarded tumour volume growth was observed. Conclusion: 211At-CCM brachytherapy has the potential to provide an alternative solution for tumour treatment.    
کلیدواژه‌های انگلیسی مقاله Brachytherapy, microspheres, radiation oncology, Astatine-211.
نویسندگان مقاله | F. Pang
Department of Intervention, Shenzhen Traditional Chinese Medicine Hospital, China


| F. Pang
Department of Intervention, Shenzhen Traditional Chinese Medicine Hospital, China


| H. Cai
Department of Nuclear Medicine, West China Hospital of Sichuan University, China


| Partha Satpathi
Department of Microbiology, Midnapore Medical College and Hospital, West Bengal, India
نشانی اینترنتی http://ijrr.com/browse.php?a_code=A-10-1-980&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
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