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Acta Medica Iranica، جلد ۶۰، شماره ۹، صفحات ۵۸۳-۵۹۳
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عنوان انگلیسی Aripiprazole Improves Spinal Cord Injury in Rats: Involvement of Inflammatory Pathways
چکیده انگلیسی مقاله Neuroinflammation causing central macrophages and microglia imbalance may contribute to spinal cord injury (SCI) pathology. There is evidence that aripiprazole (ARP) has anti-inflammatory property. Therefore, the goal of the current study was to assess the therapeutic anti-inflammatory effects of ARP on a rat model of SCI. A total of 40 male Wistar rats underwent either T9 vertebra laminectomy or used as a sham-operated group without laminectomy. They were divided into four groups: a sham-operated, three treatment (normal saline as a vehicle control versus ARP 10 and 20 mg/kg/day for three days post-surgery, first dose 30 minutes after surgery) SCI groups. Through a 28-day period, we assessed locomotor scaling and behavioral tests for neuropathic pain. At Day 28, tissue samples were evaluated for neuroinflammatory and histopathology changes using the flow cytometry, and ELISA techniques. Post-SCI ARP (10 and 20 mg/kg/day, 3 days) treatment markedly improved locomotors ability (P< 0.01) and reduced sensitivity to mechanical (P< 0.01) and thermal allodynia (P< 0.001). Additionally, ARP treatment significantly decreased tumor necrosis factor (TNF)-α level and increased interleukin (IL)-10 level in spinal cord tissue compared to control groups 28 days post SCI (P< 0.01). ARP treatment also markedly reduced expression of M1 and M2 macrophages as well as M1/M2 ratio spinal cord tissue, but decreased M1 and increased M2 and M1/M2 in dorsal root ganglion after SCI compared to controls (P< 0.001). Our data revealed a therapeutic effect of ARP treatment on SCI and showed its potential to reduce neuroinflammation as well as SCI sensory/locomotor complications.
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نویسندگان مقاله | Ali Rismanbaf
Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran


| Khashayar Afshari
Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Nazgol-Sadat Haddadi
Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Ahmad Reza Dehpour
Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Hamed Shafaroodi
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://acta.tums.ac.ir/index.php/acta/article/view/9921
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