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Journal of Medical Microbiology and Infectious Diseases، جلد ۱۰، شماره ۳، صفحات ۱۳۵-۱۴۰
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی SARS-CoV-2 Variants Screening in Burkina Faso
چکیده انگلیسی مقاله Introduction: In Sub-Saharan Africa, the data on the mutations and variants of circulating SARS-CoV-2 is limited. This study aimed to screen specific mutations and variants of SARS-CoV-2 circulating in Burkina Faso. Methods: This study included symptomatic and asymptomatic individuals who underwent diagnostic testing for SARS-CoV-2 by RT-PCR on nasopharyngeal and oropharyngeal swabs from 7 December 2021 to 12 January 2022. Samples from individuals with a Ct value ≤ 33 were selected for the variants-specific mutation screening. The screening was performed using two kits, "SNPsig® SARS-COV-2 (Escape PLEX)" and "SNPsig® VariPLEX™ (COVID-19) Real-Time PCR Assay". Results: SARS-CoV-2 prevalence was 18.9% (332/1758). A total of 113 samples (34.04%) had a Ct value less than (≤ 33), with only 20.35% (23/113) belonging to symptomatic patients. The mean age was 39.01±13 years. The Beta variant (B.1.351) was the most detected one comprising 78.8% (89/113) of variants. Gamma and Delta variants were detected at a low proportion of 0.9% (1/113). No mutation or variant was detected in seven (6.2%) samples. Conclusion: Specific mutation screening detected Beta (B.1.351), Gamma (P.1), and Delta (B.1.617.2) variants of SARS-CoV-2 circulating in Burkina Faso. The absence of mutations in some samples might suggest variants other than those detected.  
کلیدواژه‌های انگلیسی مقاله SARS-CoV-2, RT-PCR, Ct, Variant, Mutation, Burkina Faso
نویسندگان مقاله | Serge Theophile Soubeiga
Institut de Recherche en Sciences de la Santé (IRSS) /Laboratoire de Recherche Biomédicale (LaReBio), Ouagadougou, Burkina Faso


| Kinda Charlotte
University Joseph Ki-Zerbo, Laboratory of Molecular Biology and Genetics (LABIOGENE), Ouagadougou, Burkina Faso


| Abdou Azaque Zoure
Institut de Recherche en Sciences de la Santé (IRSS) /Laboratoire de Recherche Biomédicale (LaReBio), Ouagadougou, Burkina Faso


| Tegwinde Rebeca Compaoré
Institut de Recherche en Sciences de la Santé (IRSS) /Laboratoire de Recherche Biomédicale (LaReBio), Ouagadougou, Burkina Faso


| Sylvie Zida
Institut de Recherche en Sciences de la Santé (IRSS) /Laboratoire de Recherche Biomédicale (LaReBio), Ouagadougou, Burkina Faso


| Alidou Kagembega
Institut de Recherche en Sciences de la Santé (IRSS) /Laboratoire de Recherche Biomédicale (LaReBio), Ouagadougou, Burkina Faso


| Tani Sagna
Institut de Recherche en Sciences de la Santé (IRSS) /Laboratoire de Recherche Biomédicale (LaReBio), Ouagadougou, Burkina Faso


| Charlemagne Dabiré
Institut de Recherche en Sciences de la Santé (IRSS) /Laboratoire de Recherche Biomédicale (LaReBio), Ouagadougou, Burkina Faso


| Oumarou Ouedraogo
Institut de Recherche en Sciences de la Santé (IRSS) /Laboratoire de Recherche Biomédicale (LaReBio), Ouagadougou, Burkina Faso


| Nadiyah Lasisi
University Joseph Ki-Zerbo, Laboratory of Molecular Biology and Genetics (LABIOGENE), Ouagadougou, Burkina Faso


| Alexia Kabore


| Farida Milène Zida
Institut de Recherche en Sciences de la Santé (IRSS) /Laboratoire de Recherche Biomédicale (LaReBio), Ouagadougou, Burkina Faso


| Binta Fofana
Institut de Recherche en Sciences de la Santé (IRSS) /Laboratoire de Recherche Biomédicale (LaReBio), Ouagadougou, Burkina Faso


| Stéphane Somé
University Joseph Ki-Zerbo, Laboratory of Molecular Biology and Genetics (LABIOGENE), Ouagadougou, Burkina Faso


| Abdoul Nikiema
Institut de Recherche en Sciences de la Santé (IRSS) /Laboratoire de Recherche Biomédicale (LaReBio), Ouagadougou, Burkina Faso


| Dinanibè Kambire
Institut de Recherche en Sciences de la Santé (IRSS) /Laboratoire de Recherche Biomédicale (LaReBio), Ouagadougou, Burkina Faso


| Dramane Zongo
Institut de Recherche en Sciences de la Santé (IRSS) /Laboratoire de Recherche Biomédicale (LaReBio), Ouagadougou, Burkina Faso


| Issiaka Soulama
Institut de Recherche en Sciences de la Santé (IRSS) /Laboratoire de Recherche Biomédicale (LaReBio), Ouagadougou, Burkina Faso


| Charles Sawadogo
Ministère de la santé et de l’Hygiène publique, Direction des Laboratoires de Biologie Médicale (DLBM), Ouagadougou, Burkina Faso


| Sandrine Gampini
World Health Organization (WHO), Ouagadougou, Burkina Faso


| Henri Gautier Ouedraogo
Institut de Recherche en Sciences de la Santé (IRSS) /Laboratoire de Recherche Biomédicale (LaReBio), Ouagadougou, Burkina Faso
نشانی اینترنتی http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-429-1&slc_lang=en&sid=1
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موضوعات مقاله منتشر شده Diagnostic/screening methods and protocols
نوع مقاله منتشر شده Original article
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