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Iranian Journal of Microbiology، جلد ۱۴، شماره ۶، صفحات ۷۹۲-۸۰۱
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عنوان انگلیسی An overview of the sand fly salivary proteins in vaccine development against leishmaniases
چکیده انگلیسی مقاله Leishmaniases are a group of vector-borne parasitic diseases transmitted through the infected sand flies. Leishmania parasites are inoculated into the host skin along with sand fly saliva. The sand fly saliva consists of biologically active molecules with anticoagulant, anti-inflammatory, and immunomodulatory properties. Such properties help the parasite circumvent the host's immune responses. The salivary compounds support the survival and multiplication of the parasite and facilitate the disease progression. It is documented that frequent exposure to uninfected sand fly bites produces neutralizing antibodies against specific salivary proteins and further activates the cellular mechanisms to prevent the establishment of the disease. The immune responses due to sand fly saliva are highly specific and depend on the composition of the salivary molecules. Hence, thorough knowledge of these compounds in different sand fly species and information about their antigenicity are paramount to designing an effective vaccine. Herein, we review the composition of the sand fly saliva, immunomodulatory properties of some of its components, immune responses to its proteins, and potential vaccine candidates against leishmaniases.
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نویسندگان مقاله | Shima Fayaz
Department of Immunology, Pasteur Institute of Iran, Tehran, Iran; Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran


| Fariborz Bahrami
Department of Immunology, Pasteur Institute of Iran, Tehran, Iran


| Parviz Parvizi
Department of Parasitology, Pasteur Institute of Iran, Tehran, Iran


| Pezhman Fard-Esfahani
Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran


| Soheila Ajdary
Department of Immunology, Pasteur Institute of Iran, Tehran, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/3922
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