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Iranian Journal of Microbiology، جلد ۱۴، شماره ۶، صفحات ۸۶۳-۸۷۳
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عنوان انگلیسی Antimicrobial effect of silver and gold nanoparticles in combination with linezolid on Enterococcus biofilm
چکیده انگلیسی مقاله Background and Objectives: In the past few years, application of new antimicrobial e.g. nanoparticles (NPs) to treat infection caused by drug-resistant bacteria has increased. This study aimed to determine antimicrobial property of silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) in combination with linezolid on Enterococcus biofilm. Materials and Methods: A total of forty-eight isolates of Enterococcus spp. were collected and confirmed by PCR method. The synthesis of biocompatible AgNPs was performed, then analyzed by Fourier Transform Infrared spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and Transmission Electron Microscopy. We carried out minimum inhibitory concentration (MIC) and biofilm forming capacity of AgNPs and AuNPs with linezolid. Results: Twenty-two E. faecium isolates and twenty- six E. faecalis investigated in this study. Strong biofilm formation was seen in 12 (25%) of isolates, and others isolates (75%) formed moderate biofilm. AgNPs and Au-NPs size were 26 nm and 20 nm respectively. The MIC of AgNPs was 23.2 μg/ml, and AuNPs were 92.1 μg/ml and the lowest MIC was obtained 2 μg/ml in linezolid. Biofilm formation inhibitory activity by AuNPs + Linezolide and AgNPs + Linezolide 70 to 80 percent increased in average. Conclusion: The antibiofilm activity of AgNPs and AuNPs increased when both agents were used in combination with linezolid in comparison with each agent alone.
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نویسندگان مقاله | Niloofar Sabzi
Department of Microbiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran


| Rezvan Moniri
Department of Microbiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran


| Mojtaba Sehat
Trauma Research Center, Kashan University of Medical Sciences, Kashan, Iran


| Hadis Fathizadeh
Student Research Committee, Sirjan School of Medical Sciences, Sirjan, Iran; Department of Laboratory Sciences, Sirjan School of Medical Sciences, Sirjan, Iran


| Ali Nazari-Alam
Department of Microbiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran; Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/3830
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