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Physiology and Pharmacology، جلد ۲۶، شماره ۴، صفحات ۳۶۳-۳۹۴
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عنوان انگلیسی Bioactive natural products against experimental autoimmune encephalomyelitis: A pharmacokinetics review
چکیده انگلیسی مقاله Multiple sclerosis (MS) is a central nervous system (CNS) chronic disease in which axons are demyelinated and signal conduction is slowed or blocked. Unfortunately, current drugs that are used to treat MS have limited efficiency and considerable side effects. The use of bioactive natural products for treating neurodegenerative diseases has become of great interest due to their multimodal mechanism of action and potential safety. However, pharmacokinetic parameters such as bioavailability, absorption, metabolic pathways, and elimination routes are essential for evaluating the efficacy and toxicity of herbal medicines and herbal preparations in the clinic. In this review, we have summarized different pharmacokinetic parameters of neuroprotective natural products with anti-experimental autoimmune encephalomyelitis (EAE) effects and recent developments in strategies to improve their bioavailability and effectiveness.
کلیدواژه‌های انگلیسی مقاله Multiple sclerosis, Demyelination, Natural products, Pharmacokinetics, Experimental autoimmune encephalomyelitis
نویسندگان مقاله | Leila Mohtashami
Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Abolfazl Shakeri
Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Behjat Javadi
Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-11-1533-1&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Nervous system (others)
نوع مقاله منتشر شده Review
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