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Physiology and Pharmacology، جلد ۲۶، شماره ۴، صفحات ۴۵۱-۴۵۸
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عنوان انگلیسی Fullerene C60 nanoparticle attenuates pain and tumor necrosis factor-α protein expression in the hippocampus following diabetic neuropathy in rats
چکیده انگلیسی مقاله Introduction: Diabetic neuropathy is a common complication of diabetes mellitus. It is associated with nerve damage due to oxidative stress and high levels of pro-inflammatory mediators. In the present study, we examined the anti-nociceptive effects of Fullerene nanoparticle, as a potent anti-oxidant, during diabetic neuropathy. Methods: Diabetes mellitus induced through injection of streptozotocin (STZ) (40 mg/kg). Four groups were used in the study as follows: the control, control+fullerene, diabetes, and diabetes +fullerene groups. All four groups received sesame oil. Treatment rats received fullerene C60 (1mg/kg/day) for 9 weeks by intra-gastric gavage. Then, cold allodynia, histology, and tumor necrosis factor-α (TNF- α) protein expression of the hippocampus were measured 9 weeks after injection of STZ. Results: Our data revealed that STZ induces cold allodynia in both hind paws and increases the TNF- α protein expression in the hippocampus. Furthermore, STZ induces neural degeneration in the hippocampus. Additionally, fullerene C60 significantly attenuated cold allodynia and TNF- α protein expression. Also, fullerene C60 has neuro-protective effects on hippocampal neurons. However, fullerene C60 did not significantly reduce serum glucose levels in diabetic animals. Conclusion: Our data suggest that fullerene C60 likely suppressed pain, and neural loss by inhibitory effects on TNF- α protein expression in the hippocampus during diabetes.
کلیدواژه‌های انگلیسی مقاله Fullerene C60, Diabetic Neuropathy, TNF-α, Hippocampus
نویسندگان مقاله | Fariba Namdar
Pediatric Urology and Regenerative Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran


| Farideh Bahrami
Department of Physiology and Medical Physics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran


| Zahra Bahari
Department of Physiology and Medical Physics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran


| Bahram Ghanbari
Department of Chemistry, Sharif University of Technology, Tehran, Iran


| Shima Shahyad
Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran


| Mohammad Taghi Mohammadi
Department of Physiology and Medical Physics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-10-1536-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Nervous system (others)
نوع مقاله منتشر شده Experimental research article
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