| چکیده انگلیسی مقاله |
Introduction: Combretum dolichopetalum (CD) is commonly found in the Eastern part of Nigeria where it is used to relieve menstrual pain, enhance labour, facilitate the removal of placenta and promote a rich milk supply after delivery. This study investigates the effect of prenatal consumption of Combretum dolichopetalum by pregnant albino rats on haematological, and biochemical parameters as well as pregnancy outcome. Methods: Mature inbred healthy female albino rats of normal estrus cycles that were 2-3 months of age weighting 120-180 g were used for the study. Examination of the estrus cycle, the introduction of male rats at pro-estrus, and confirmation of pregnancy were adopted using standard method. After initiation of pregnancy, fifty (50) rats were placed in five groups comprising ten rats per group. Distilled water was administered to rats in Group 1 which served as control while rats in Groups 2, 3, 4, and 5 received 100, 200, 400 and 800 mg/kg of Combretum dolichopetalum methanol leaf extract (CDLE) from day 15 to 20 of pregnancy using oral gavage, respectively. Maternal weight, haematological parameters (full blood count), biochemical parameters (renal and liver indices), gestational length, and litter size were measured using standard methods. Results: The result showed a decrease in maternal weight, postpartum weight retained and gestational length, an increase in haematological parameters, and no changes in the renal and liver indices. Conclusion: This study indicates that CDLE during prenatal did not influence the pregnancy outcome but was beneficial in decreasing postpartum weight retained without any visible sign of toxicity. |
| نویسندگان مقاله |
| Chinedum U. Emelike
Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Alex Ekwueme Federal University, Ndufu-Alike, Abakaliki, Ebonyi State, Nigeria
| Ugochukwu S. B. Anyaehie
Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Nigeria
| Eghosa E. Iyare
Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Nigeria
| Chiemeziem A. Obike
Department of Biochemistry, Michael Okpara University of Agriculture Umudike, Umuahia, Abia State, Nigeria
| Chinyere Aloke
Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medical Sciences, Alex Ekwueme Federal University, Ndufu-Alike, Abakaliki, Ebonyi
| Ofovwe O. Ekakitie
Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Alex Ekwueme Federal University, Ndufu-Alike, Abakaliki, Ebonyi State, Nigeria
| John A. O. Chukwu
Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, Ebonyi State University, Abakaliki, Ebonyi State, Nigeria
| Ndukwe Maduka
Department of Biological Sciences, College of Natural and Applied Sciences, Wellspring University, Benin City, Edo State, Nigeria
| Odochi O. Chukwu
Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Alex Ekwueme Federal University, Ndufu-Alike, Abakaliki, Ebonyi State, Nigeria
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