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Physiology and Pharmacology، جلد ۲۶، شماره ۴، صفحات ۴۶۸-۴۷۹
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چکیده فارسی مقاله
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عنوان انگلیسی Effect of cell-free supernatant of Bifidobacterium bifidum combined with chitosan biodegradable film on full thickness wound healing in rats
چکیده انگلیسی مقاله Introduction: Wound healing is one of the most critical issues human has been faced since the beginning of creation. Biodegradable polymers are of particular importance. In this study, cell-free supernatant (CFS) of Bifidobacterium bifidum combined with chitosan (CH) film was evaluated as a wound dressing. Methods: Biodegradable films (CH and CFS/CH), as a novel wound dressing, were prepared. For the evaluation of dressing efficacy, 45 male Wistar rats weighing 200-250 g were randomly divided into 3 groups: negative control (without wound treatment), positive control (wound treatment by CH film), and probiotic (wound treatment by CFS/CH film). One full thickness wound was created on the dorsal area of the animals. The wound in positive control and probiotic groups were immediately covered by CH and CFS/CH dressing, respectively. Wound healing process was evaluated by macroscopic observation and histological analysis. During the treatment the expression of IL-1, TGF-B and IL-6 were assayed by qRT-PCR. Results: Our results showed different infiltration patterns of macrophages, fibroblasts, and neutrophils in CFS/CH treated group. Enhanced disposition of collagen and elastin caused improvement of wound healing process by the film. Based on the gene expression results, use of CFS/CH film caused improvement in wound healing kinetic. Conclusion: The biodegradable film based on chitosan and CFS of B. bifidum improves the wound healing process.
کلیدواژه‌های انگلیسی مقاله Wound healing, Chitosan, Cell free supernatant, Biodegradable-film, Cytokines
نویسندگان مقاله | Atena Bazjou
Department of Microbiology, Arak Branch, Islamic Azad University, Arak, Iran


| Parvaneh Jafari
Department of Microbiology, Arak Branch, Islamic Azad University, Arak, Iran


| Azam Marjani
Department of Chemistry, Arak Branch, Islamic Azad University, Arak, Iran


| Neda Akbari
Department of Microbiology, Arak Branch, Islamic Azad University, Arak, Iran
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-10-1421-2&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pharmacokinetics/Dynamics
نوع مقاله منتشر شده Experimental research article
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