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Iranian Journal of Pediatric Hematology and Oncology، جلد ۱۳، شماره ۱، صفحات ۴۳-۵۱
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عنوان انگلیسی Predicting Factors of Atherosclerosis in Children with Beta-Thalassemia Major
چکیده انگلیسی مقاله Background: Atherosclerosis is an important cardiovascular disorder in beta-thalassemia major patients. The present study aimed to predict factors of atherosclerosis in children with beta-thalassemia major. Materials and Methods: This cross-sectional study was conducted on 36 patients with beta-thalassemia major and 36 healthy children as the control group. The carotid intima-media thickness (CAIMT) and osteoprotegerin (OPG) were compared between groups. Results: The mean age of the patients in the case and control groups were 13.5 ± 3.7 and 13 ± 3.1 years old, respectively. Significant differences in CAIMT in the right (P = 0.001) and left (P = 0.001) arteries were recorded between the two groups. The mean serum OPG in the beta-thalassemia group was significantly higher than the control group (3.9 ng/ml and 1.4 ng/ml, respectively, P=0.001). Conclusion: CAIMT is a non-invasive method for diagnosing atherosclerosis. According to the significant difference between groups, serum OPG could be helpful in the diagnosis of early atherosclerosis in beta-thalassemia major.
کلیدواژه‌های انگلیسی مقاله Atherosclerosis, Beta-Thalassemia, Osteoprotegerin
نویسندگان مقاله | Bahram Darbandi
Guilan University of Medical Sciences, Rasht, Iran.


| Nasim Ghorbannezhad
Guilan University of Medical Sciences, Rasht, Iran.


| Adel Baghersalimi
Guilan University of Medical Sciences, Rasht, Iran.


| Shahin Koohmanaee
Guilan University of Medical Sciences, Rasht, Iran.


| Afagh Hassanzadeh Rad
Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran


| Zahra Atrkar Roshan
Guilan University of Medical Sciences, Rasht, Iran.


| Saeid Anvari
Guilan University of Medical Sciences, Rasht, Iran.


| Setila Dalili
Guilan University of Medical Sciences, Rasht, Iran.


| Manijeh Tabrizi
Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-636-5&slc_lang=en&sid=1
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