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Acta Medica Iranica، جلد ۶۰، شماره ۱۱، صفحات ۶۸۰-۶۸۷
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عنوان انگلیسی Fresh-Packed RBC Infusion Diminishes Acute AlP Poisoned-Patients' Mortality Rate: A Clinical Trial
چکیده انگلیسی مقاله Accidental or intentional poisoning with Aluminum phosphide (AlP) is associated with severe complications such as metabolic acidosis, cardiac failure, and death. Previous animal experiments demonstrated that fresh-packed RBC is protective in an experimental model of AlP poisoning. The aim of this study was to assess the effect of fresh-packed RBC on survival in patients admitted to a referral hospital due to AlP poisoning in a randomized clinical trial. Eighty-two patients were admitted to Clinical Toxicology Unit at Baharloo Hospital due to acute AlP poisoning after approval by the Iranian Registry of Clinical Trials (registration reference: IRCT20180428039443N1). All patients received standard treatment, and forty-one of them received fresh-packed RBC. There was no significant difference between groups in the underlying characteristics, including vital signs and laboratory investigations. But interestingly, the mortality rate was meaningfully decreased (difference: 31.7%, 95% CI: 0.10-0.52) in patients receiving fresh-packed RBC (10 deaths/31 survived; 24.4% mortality) in comparison to standard treatment patients (23 deaths/18 survived; 56.1% mortality). Furthermore, fresh-packed RBC substantially improved the GCS, systolic/diastolic blood pressure, ST changes, and pH 12- and- 24 hours after admission. This study showed that fresh-packed RBC infusion alongside standard supportive treatment leads to a decrease in mortality rate; also, it provided evidence for a protective role of fresh-packed RBC in the management of patients with acute AlP poisoning.
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نویسندگان مقاله | AhmadReza Dehpour


| Nastaran Rahimi
Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.


| Behnam Behnoush
Department of Forensic Medicine, Tehran University of Medical Sciences, Tehran, Iran.


| Hamed Hosseini
Center for Research and Training in Skin Diseases and Leprosy, TUMS, Tehran, Iran.


| Amir A Fakhrabadi
Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.


| Nina Javadian
Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.


| Nasrin B arzegari Dahaj
Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.


| Adeleh Maleki
Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.


| Seyed Morteza Tabatabaei
Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran Iran
نشانی اینترنتی https://acta.tums.ac.ir/index.php/acta/article/view/10359
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