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Acta Medica Iranica، جلد ۶۰، شماره ۱۱، صفحات ۷۰۷-۷۱۳
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عنوان انگلیسی Relationship Between Serum 25-Hydroxy Vitamin D Level and Breast Cancer Prognostic Factors
چکیده انگلیسی مقاله Vitamin D deficiency plays an important role in the development of various diseases, including cancer. Regarding the high prevalence of breast cancer and vitamin D deficiency in Iran, this study aimed to investigate the relationship between vitamin D deficiencies and prognostic factors in breast cancer. This descriptive-analytical cross-sectional study was performed from March 2015 to March 2017 at Imam Reza hospital in Kermanshah city, Iran. 145 breast cancer patients with pathologic confirmation and before the neoadjuvant or adjuvant treatments were included by simple and convenient sampling. Serum 25(OH) D levels were measured in all patients before receiving treatment. The collected data were analyzed by using SPSS software (version. 20), and the relationship between the levels of 25(OH) D and the studied factors was assessed by inferential statistical tests in each group. The results showed that there was a statistically significant direct relationship between serum vitamin D levels and some factors, including age, ER, and PR, but a significant inverse relationship was observed between serum vitamin D levels and the level of ki67 and metastasis. There was no statistically significant relationship between the mean serum level of vitamin D and tumor grade and P53 receptor, but high levels of vitamin D were associated with low-grade tumors and P53 negativity. According to the findings, lower levels of vitamin D can be associated with higher levels of ki67 and P53, higher-grade breast cancer, a higher rate of metastases, as well as lower percentage of hormone receptor positivity.  
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نویسندگان مقاله | Negin Farshchian
Department of Radiation Oncology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Marjan Rashidi
Clinical Research Development Center, Imam Reza Hospital, Kermanshah, Iran


| Sahel Heydarheydari
Department of Medical Physics, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Nazanin Farshchian
Associate Professor of Radiology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
نشانی اینترنتی https://acta.tums.ac.ir/index.php/acta/article/view/9862
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