این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Journal of Research in Medical Sciences، جلد ۲۷، شماره ۲۴، صفحات ۲۰۲۲-۲۷
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عنوان انگلیسی Serum pepsinogen level as a biomarker for atrophy, reflux esophagitis, and gastric cancer screening in Indonesia
چکیده انگلیسی مقاله Background : Chronic dyspepsia’s symptoms are frequently seen in primary to tertiary healthcare in Indonesia. This study aimed to describe the potential usability of pepsinogen (PG) values in determining gastric mucosal conditions, including superficial gastritis and atrophic gastritis. Materials and Methods : We recruited 646 adult dyspeptic patients and then analyzed PG values (including PGI, PGII, and PGI/II ratio) with endoscopic findings, gastric mucosal damages, and Helicobacter pylori infection. The gastric mucosal damage and H. pylori infection were evaluated using histological examination based on the updated Sydney system. Results : Among 646 enrolled patients, 308 (47.2%), 212 (32.8%), 91 (14.1%), 34 (5.2%), and 1 (0.2%) patient were diagnosed with normal mucosa, gastritis, reflux esophagitis, peptic ulcer disease, and gastric cancer, respectively. Significant differences in PGI, PGII, and PGI/II ratio values were observed among ethnic groups (all P < 0.01). The PGI and PGII levels were significantly higher and PGI/II was significantly lower in H. pylori?infected patients than in uninfected ones (all P < 0.001). The optimal cutoff value for PGII and PGI/II was 12.45 ng/mL with an area under the curve (AUC) value of 0.755 (0.702–0.811), sensitivity 59.3%, and specificity 77.1%; and 4.75 with AUC value of 0.821 (0.763–0.855), sensitivity 81.5%, and specificity 78.7%, respectively, to determine moderate–severe atrophy. Conclusion : Serum PG levels, a useful biomarker, represent the endoscopic findings, especially for reflux esophagitis. In addition,
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نویسندگان مقاله | Muhammad Miftahussurur


| Langgeng Agung Waskito


| Ari Fahrial Syam


| Iswan Abbas Nusi


| I Dewa Nyoman Wibawa


| Yudith Annisa Ayu Rezkitha


| Kartika Afrida Fauzia


| Gontar Alamsyah Siregar


| Fardah Akil


| Bradley Jimmy Waleleng


| Alexander Michael Joseph Saudale


| Azzaki Abubakar


| Hasan Maulahela


| Marselino Richardo


| Abdul Rahman


| Yoma Sari Namara


| Eko Sudarmo


| Pangestu Adi


| Ummi Maimunah


| Poernomo Boedi Setiawan


| Dalla Doohan


| Tomohisa Uchida


| Astri Dewayani


| Purwo Sri Rejeki


| Titong Sugihartono


نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/11402
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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