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Journal of Research in Medical Sciences، جلد ۲۷، شماره ۲۴، صفحات ۲۰۲۲-۲۷
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چکیده فارسی مقاله
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عنوان انگلیسی The tangled web of dyslipidemia and cancer: Is there any association?
چکیده انگلیسی مقاله Cancer is a primary cause of mortality around the world and imposes a significant physiological, psychological, and financial burden on patients. Lipids regulate cell cycle progression and affect cell proliferation, migration, and apoptosis. Therefore, alterations in serum lipid levels might contribute to carcinogenesis. In this article, we review the relationships between triglyceride (TG), total cholesterol, high?density lipoprotein cholesterol (HDL?C), and low?density lipoprotein cholesterol (LDL?C) levels and different types of cancer. Then, we examine the association between cancer and familial hypercholesterolemia. Finally, we evaluate the impact of statins on different types of cancer. Increased total cholesterol has been reported to increase cellular proliferation and angiogenesis in tumors and inhibit apoptosis. Increased LDL?C has been reported to induce inflammation and increase susceptibility to oxidative damage. HDL?C has anti?oxidation, anti?inflammatory, and ntiproliferative properties. Increased levels of serum TG can induce oxidative stress and a chronic inflammatory state and therefore ontribute to the proliferation and progression of cancer cells. Statins decrease downstream products of cholesterol synthesis that are crucial in cell proliferation and growth. Thus, lipid components can have prognostic value in cancer and management of serum lipid levels through lifestyle changes and medical therapy can be beneficial in cancer prevention and treatment.
کلیدواژه‌های انگلیسی مقاله Cancer, cholesterol, dyslipidemia, high?density lipoprotein cholesterol, low?density lipoprotein cholesterol, statins
نویسندگان مقاله | Sina Neshat


| Abbas Rezaei


| Armita Farid


| Rojin Sarallah


| Salar Javanshir


| Sarina Ahmadian


| Gelayol Chatrnour


| Padideh Daneii


| Kiyan Heshmat Ghahdarijani


نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/11400
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Review Article
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