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Middle East Journal of Digestive Diseases، جلد ۱۴، شماره ۴، صفحات ۴۶۲-۴۷۲
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عنوان انگلیسی The Effects of Risk Factors on One- and Five-Year Survival of Patients with Gastric Cancer in Isfahan in 2016
چکیده انگلیسی مقاله Background: Gastric cancer (GC) is a frequent and multifactorial malignancy worldwide. The aim of this study was to investigate the relationship between some risk factors of GC and the 1-year or 5-year survival rates in newly diagnosed patients in Isfahan in 2016. Methods: We included 274 newly diagnosed patients in this survival analysis from a database of 484 GC cases. We used a checklist to collect information. To inform about missed data, we call the patients or their families in non-survived cases. We evaluated each patient’s age, sex, body mass index (BMI), education, salt, salty foods, and red meat consumption. In addition, we asked patients about the intake of fresh fruits and vegetables, tobacco smoking, opium usage, and alcohol consumption. We surveyed the patient’s job, physical activity, helicobacter pylori ( H. pylori ) infection, family history of GC, history of gastric surgery, and survival status after 1 or 5 years. Variables were evaluated between survived and dead patients and compared for means and frequencies using the independent samples t-test or Mann-Whitney, or Chi-square test. The univariate relationship of each risk factor, with 1- and 5-year survival, was examined by the Log-Rank test and the Kaplan-Meyer method and their multivariate relationship with Cox regression. Results: 1- and 5-year survived patients were younger than dead patients with GC (P< 0.001; HR for 1-year survival: 1.014, 95% CI: 0.997 to 1.030; HR for 5-year survival: 1.005, 95% CI: 0.994 to 1.017), and had more frequent higher educational levels (P< 0.05; HR for 1-year survival: 1.887, 95% CI: 1.046 to 3.406; HR for 5-year survival: 1.482, 95% CI: 0.987 to 2.223). The death rate after 5 years was higher in men than in women (P= 0.009; HR: 1.009, 95% CI: 0.593 to 1.717) and depended on the job status of the patients (P= 0.021). The other studied variables were not significantly different between 1- or 5-year survived and dead patients. Conclusion: GC development depends on genomic changes, environmental factors, and lifestyle status. But all risk factors that play a role in its development are not notable for a patient’s survival. We suggest that risk factors for these patients’ survival become elucidated in future studies. It helps to gather the necessary pieces of evidence for the enhancement of survival in patients with GC.
کلیدواژه‌های انگلیسی مقاله Gastric cancer,Survival,Hazard ratio,Lifestyle
نویسندگان مقاله | Elham Tabesh
Medical student, Isfahan University of Medical Sciences, Isfahan, Iran


| Nima Karimi
Assistant Professor, Isfahan gastroenterology and hepatology research center (IGHRC), Isfahan University of Medical Sciences, Isfahan, Iran


| Maryam Soheilipour
Gastroenterology and hepatology Fellowship, Isfahan gastroenterology and hepatology research center (IGHRC), Isfahan University of Medical Sciences, Isfahan, Iran.


| Mohamad Rezaeisadrabadi
Isfahan cancer registry, Isfahan University of Medical Sciences, Isfahan, Iran


| Zahra Ravankhah
Professor of Gastroenterology and Hepatology, Isfahan gastroenterology and hepatology research center (IGHRC), Isfahan University of Medical Sciences, Isfahan, Iran


| Peyman Adibi


نشانی اینترنتی http://mejdd.org/index.php/mejdd/article/view/2692
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi) 10.15171/middle east j di.v14i4.2692
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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