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Journal of Arthropod-Borne Diseases، جلد ۱۶، شماره ۲، صفحات ۱۲۰۷-۱۲۰۷
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عنوان انگلیسی Phytochemical Composition and Bioassay on Iranian Teucrium polium Ex-tracts against Anopheles stephensi (Diptera: Culicidae)
چکیده انگلیسی مقاله Background: Anopheles stephensi is an important malaria vector mosquito in Iran and other western Asian countries. In many human communities, plant products have been used traditionally instead of synthetic pesticides for mosquito control due to their minimal hazardous effects. Teucrium polium, known popularly as felty germander, has been intro-duced in Persian Medicine (PM) as an insect repellent from a long time ago. Methods: The present study was undertaken to evaluate repellent and larvicidal activity of dichloromethane (DCME-TP) and ethanolic extracts (EE-TP) of T. polium against An. stephensi under laboratory conditions. The possible chemi-cal components of the extracts were also investigated through gas chromatography/mass spectrometry (GC-MS) tech-nique. Results: Based on the results, DCME-TP showed better repellent activity than EE-TP with 56.67 and 28.33 % protec-tion, respectively. Larvicidal activity of DCME-TP with 49.41% mortality was also higher than EE-TP (20.24%). The main identified constituents of DCME-TP were long chain alkanes, phenol, aromatic ester, oxaspiro and triterpenoid. While phenolic and aliphatic acid were only the identified components in EE-TP. It is notable that lupeol was detected in DCME of T. polium for the first time. Conclusion: DCME-TP can be considered as a new herbal candidate to control An. stephensi mosquitoes. Further stud­ies are required on this extract for the fractionation and identification of the active compounds, and the evaluation of their bioactivity in the laboratory and field.
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نویسندگان مقاله | Saeedeh Ghafari
Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Azar Tahghighi
Medicinal Chemistry Laboratory, Clinical Research Department, Pasteur Institute of Iran, Tehran, Iran


| Khadijeh Shamakhte
Department of Biochemistry, Payame Noor University, Tehran, Iran


| Hamzeh Alipour
Research Center for Health Sciences, Institute of Health, Shiraz University of Medical Sciences, Shi-raz, Iran


| Naseh Maleki-Ravasan
Department of Parasitology, Pasteur Institute of Iran, Tehran, Iran


| Mehdi Nateghpour
Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://jad.tums.ac.ir/index.php/jad/article/view/1207
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