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Basic and Clinical Neuroscience، جلد ۱۴، شماره ۱، صفحات ۰-۰
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عنوان انگلیسی The Effect of Aerobic Training with the Consumption of Probiotic on the Myelination of Nerve Fibers in Cuprizone-Induced Demyelination Mouse Model of Multiple Sclerosis
چکیده انگلیسی مقاله Introduction: Extensive human and animal research shows that exercise has beneficial effects on multiple clinical outcomes for patients suffering from multiple sclerosis (MS). This research was an attempt to address the effect of aerobic training with the consumption of probiotic on the myelination of nerve fibers in a cuprizone-induced demyelination mouse model of MS. Methods: Mice, which were exposed to cuprizone (CPZ) for 13 weeks, were subjected to motor and balance tests in week 5. They (n = 5 per group) were assigned to five groups of control (C), MS, MS with exercise (MS + Exe), MS with probiotic (MS + Pro), and MS with probiotic and exercise (MS + Pro + Exe) randomly. The exercise groups conducted aerobic exercises 5 days/week for 60 days. The mice took in probiotic by gavage. Performance and balance tests were repeated when the eight-week protocol of exercise and probiotic consumption was finished. One day after these interventions, they were sacrificed in order to be subject to biochemical and molecular biology assays. Results: The results showed that myelin basic protein (MBP) was increased in the MS + Pro + Exe, MS + Pro, and MS + Exe compared to the MS group (P< 0.05). The mRNA of nestin showed an increase in MS + Pro + Exe, MS + Exe, and MS + Pro groups compared to the MS group, but this increase in MS + Pro + Exe and MS + Exe groups was not significant compared to the control and MS groups (P>0.05). Conclusion: According to the results, lifestyle interventions can effectively alleviate demyelinating-inflammatory processes that happen in the brains of MS patients.
کلیدواژه‌های انگلیسی مقاله Myelination, Multiple sclerosis, Exercise, Lactobacillus plantarum, Cyclohexanes
نویسندگان مقاله | Donya Sajedi
Department of Physical Education and Sports Sciences, Faculty of Humanities, Rasht Branch, Islamic Azad University, Rasht, Iran.


| Ramin Shabani
Department of Physical Education and Sports Sciences, Faculty of Humanities, Rasht Branch, Islamic Azad University, Rasht, Iran.


| Alireza Elmieh
Department of Physical Education and Sports Sciences, Faculty of Humanities, Rasht Branch, Islamic Azad University, Rasht, Iran.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-3104-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Clinical Neuroscience
نوع مقاله منتشر شده Original
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