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Journal of Reproduction and Infertility، جلد ۲۴، شماره ۱، صفحات ۴۳-۴۹
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عنوان انگلیسی The Effects of Chemotherapy on the Levels of Serum Anti-Müllerian Hormone in Patients with Gestational Trophoblastic Neoplasia
چکیده انگلیسی مقاله Background: Gestational trophoblastic neoplasia (GTN) is a group of tumors highly responsive to chemotherapy. It has been suggested that cancer therapies have detrimental effects on female fertility. Anti-Müllerian hormone (AMH) is considered fertility potential and ovarian reserves in women. The aim of this study was to compare serum AMH levels between the patients with GTN treated with chemotherapy and the patients with hydatidiform mole who underwent suction curettage without receiving any chemotherapy.  Methods: In 35 patients with GTN, serum AMH levels were measured before suction curettage and after the administration of chemotherapy and compared with serum AMH levels measured in 35 patients with hydatidiform mole, who did not receive any chemotherapy as a control. In controls, serum levels of AMH were measured before suction curettage and at the time when beta human chorionic gonadotrophin (ß-hCG) levels approached zero concentration.  Results: The mean serum AMH levels in the GTN group were significantly lower than those measured in the control group after chemotherapy. In addition, serum AMH levels measured after intervention in each group significantly decreased compared to the basal levels (p=0.034). Serum AMH levels showed significant differences between the patients who received chemotherapy regimens with methotrexate (MTX) alone, actinomycin-D (Act-D) alone, or the combination of MTX and Act-D (p=0.001).  Conclusion: Our study showed that fertility preservation is of great importance in patients with GTN treated with chemotherapy. Furthermore, both MTX and Act-D could have potential adverse effects on ovarian reserve.
کلیدواژه‌های انگلیسی مقاله Anti- mullerian hormone, Chemotherapy, Fertility, Gestational trophoblastic neoplasia, Hydatidiform mole
نویسندگان مقاله | Mehrangiz Zamani
Fatemieh Hospital, Hamadan University of Medical Sciences and Health Services, Hamadan, Iran, Hamadan, Iran


| Fatemeh Mohsenpour
Fatemieh Hospital, Hamadan University of Medical Sciences and Health Services, Hamadan, Iran, Hamadan, Iran


| Faezeh Torkzaban
Faculty of Rehabilitation, Hamadan University of Medical Sciences and Health Services, Hamadan, Iran


| Nazanin Atrvash
Fatemieh Hospital, Hamadan University of Medical Sciences and Health Services, Hamadan, Iran, Hamadan, Iran


| Amir Majlesi
Besat Hospital, Hamadan University of Medical Sciences and Health Services, Hamadan, Iran


| Amirfazel Torkzaban
National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://www.jri.ir/article/140173
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