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Middle East Journal of Cancer، جلد ۱۴، شماره ۱، صفحات ۱۳۶-۱۴۵
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عنوان انگلیسی The Impact of Body Mass Index on Pathological Response and Survival Outcome after Neoadjuvant Chemotherapy in Localized Bladder Cancer
چکیده انگلیسی مقاله Background: Neoadjuvant chemotherapy (NAC) grants a modest survival benefit in localized muscle-invasive bladder cancer (MIBC). We evaluated the pathological response and survival outcome after NAC in stage II and IIIA MIBC and their correlation with body mass index (BMI).Method: Our retrospective study included stage II (T2 N0) and IIIA (T3 N0, T4 N0, T1-4 N1) MIBC. They received NAC followed by radical cystectomy. The patients were categorized into level I: a BMI of 18.5 – 24.9 kg/m2, level II: a BMI of 25-29.9 kg/m2, and level III: a BMI of ≥ 30 kg/m2.Results: 103 patients with localized MIBC were included. The median age was 63 years; 35 patients (34.0%) belonged to level I, 40 patients (38.8%) belonged to level II, and 28 patients (27.2%) belonged to level III. Smoking status was more common in level II (51.0%) and level III (36.7%) (P < 0.001). Only 18 patients had ECOG PS 2, all belonging to level III (P < 0.001). After NAC, the pCR was 34.3%, 25%, and 10.7% of level I, level II, and level III (P = 0.03), respectively. Of 19 patients who passed away, 10 patients belonged to level III and 6 patients belonged to level II (P = 0.007). For level I, level II, and level III, the disease-free survival was 23.2 months, 12.7 months, and 10.7 months and the overall survival was 61.9, 52.3, and 28.7 months, respectively.Conclusion: Obesity and overweight could be predictive and prognostic markers in localized MIBC. These factors are associated with low pCR after NAC, poor disease-free survival, and overall survival.
کلیدواژه‌های انگلیسی مقاله Urinary bladder neoplasms, Body mass index, Neoadjuvant chemotherapy
نویسندگان مقاله Amrallah Mohammed |
Medical Oncology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Fifi Elsayed |
Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Suez Canal University, Egypt

Reham Salem |
Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt

نشانی اینترنتی https://mejc.sums.ac.ir/article_48461_e789b2d1ec9e8158004830ab88864634.pdf
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