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Avicenna Journal of Phytomedicine، جلد ۱۳، شماره ۱، صفحات ۴۵-۵۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The effects of phytosomal curcumin supplementation on clinical symptoms, and inflammatory and oxidative stress biomarkers in patients with migraine: A protocol for a randomized double-blind placebo-controlled trial
چکیده انگلیسی مقاله Objective: Migraine is one of the most common diseases. Curcumin with anti-oxidative and anti-neuroinflammatory properties might have beneficial effects in migraine patients. This study will be conducted to evaluate the effects of a phytosomal preparation of curcumin on clinical signs, oxidative stress, and inflammatory parameters in patients with migraine.Materials and Methods: This is a randomized, double-blind, placebo-controlled, clinical trial in which, 60 patients with migraine will be assigned to receive a daily dose of 250 mg of phytosomal curcumin for 8 weeks (intervention group) or 250 mg maltodextrin as a placebo for the same duration (control group). Before and after the study, frequency, duration, and severity of the attacks, quality of life and sleep, mood status, high-sensitivity C-reactive protein (hs-CRP), Nitric Oxide (NO), and oxidative stress factors will be measured.Conclusion: It seems that phytosomal formulation of curcumin (a solid dispersion preparation of curcumin with phosphatidylserine) with high bioavailability, can cross the blood-brain barrier (BBB) and result in decreased neuroinflammation, oxidative stress, and neurotoxicity. This way, phytosomal curcumin might lead to reduction of headaches and other complications of migraine and increase the quality of life of patients with migraine. 
کلیدواژه‌های انگلیسی مقاله Curcumin, Phytosomal curcumin, Migraine, Inflammation, Headache
نویسندگان مقاله | Mehrnaz Shojaei
Student Research Committee, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran


| Amirhossein Sahebkar
Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Fariborz Khorvash
Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


| Soheil Fallahpour
Department of Neurosurgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


| Gholamreza Askari
Nutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran


| Mohammad Bagherniya
Nutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_21242.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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