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Avicenna Journal of Phytomedicine، جلد ۱۳، شماره ۱، صفحات ۵۸-۶۹
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عنوان انگلیسی The effect of hydroalcoholic extract of Cichorium intybus leaf on aryl hydrocarbon receptor expression in the testis of Wistar rats exposed to cigarette smoke
چکیده انگلیسی مقاله Objective: Cigarette smoke (CS) contains compounds such as reactive oxygen species (ROS). Oxidative stress caused by excessive ROS eventually leads to germ cell apoptosis and male infertility. The leaves of Cichorium intybus (chicory) are rich in natural antioxidants, but their protective effects on the adverse effects of CS on testicular tissue have not been studied.Materials and Methods: 24 Wistar rats were classified into four groups: control, extract: treatment with chicory extract (200 mg/kg body weight/day) for 13 weeks, smoke: exposed to CS for 13 weeks, and smoke + extract: exposed to CS and treated with the C. intybus extract. Histological and biochemical analyses and apoptosis assay were done, and Ahr, and Cyp1a1 expression was determined.Results: Treatment with C. intybus compensated for the reduction of Sertoli cells, spermatogonia, spermatocytes, and spermatids caused by CS. Chicory extract reduced free radicals and improved antioxidant status. The lowest and highest percentage of apoptotic cells was observed in the extract and smoke groups, respectively, while simultaneous treatment with C. intybus extract led to a significant reduction of apoptotic cells. The mean Ahr levels in the control, extract, smoke and smoke + extract groups were 1.00±0.57, 1.93±0.25, 5.98±0.42, and 0.62±0.22, respectively (p˂0.05). The mean levels of Cyp1a1 expression in the control, extract, smoke and smoke + extract groups were 1.00±0.31, 2.28±0.65, 5.55±0.40, and 0.21±0.23 (p˂0.05).Conclusion: The C. intybus extract probably affected Cyp1a1 expression by downregulation of Ahr. These led to a decrease in free radicals and apoptosis, and an improvement in antioxidant status.
کلیدواژه‌های انگلیسی مقاله Cichorium Intybus, Spermatogenesis, Malondialdehyde, Caspase-3, Cigarette smoke
نویسندگان مقاله | Maryam Hashemi
Department of Animal Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran


| Mahnaz Azarnia
Department of Animal Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran


| Zahra Hajebrahimi
A&S Research Institute, Ministry of Science Research and Technology, Tehran, Iran


| Samad Nejad Ebrahimi
Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, Tehran, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_21307.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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