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Avicenna Journal of Phytomedicine، جلد ۱۲، شماره ۶، صفحات ۶۲۷-۶۳۷
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عنوان انگلیسی The effect of high intensity interval training with beetroot (Beta vulgaris) juice supplementation on serotonin and dopamine receptors expression, anxiety and depression in middle-aged diabetic rats
چکیده انگلیسی مقاله Objective: The aim of this study was to evaluate the effect of four weeks of high intensity interval training (HIIT) with beetroot juice supplementation (BJ) on serotonin and dopamine receptors in hippocampal tissue, as well as anxiety and depression in middle-aged diabetic rats.Materials and Methods: In this experimental study, 28 diabetic female rats (55 mg/kg, induced by streptozotocin) aged 12-14 months, weighing 280-320 g, were divided into (1) diabetic control (DC), (2) BJ, (3) HIIT, and (4) HIIT+BJ groups. Also, 7 healthy rats were included in the healthy control (HC) group to evaluate the effect of diabetes induction on the research variables. HIIT was performed for four weeks, 4 sessions per week (70-95% of maximum speed at high intensities; 50-60% of maximum speed at low intensities). Also, BJ was fed daily to rats at a dose of 10 ml/kg.Results: Hippocampal expression of dopamine receptor-1 (Dop.R), 5-hydroxytryptamine receptor (5-HT. R), open arm entry percentage (OAE%) and movement rate in the HIIT, BJ and HIIT+BJ groups were significantly higher than the DC group. In the HIIT+BJ group, open arm time percentage (OAT%) was higher than the DC group. Levels of Dop.R gene expression were more affected by HIIT, and levels of 5-HT. R were more affected by BJ supplementation; also, HIIT+BJ had a synergistic effect on reducing anxiety and depression.Conclusion: Although HIIT was more effective than BJ and HIIT+BJ on Dop.R and BJ supplementation on 5-HT.R and improved anxiety and depression, both of HIIT and BJ were complementary in improving dopamine and serotonin receptor-dependent anxiety and depression and enhanced each other's effects.
کلیدواژه‌های انگلیسی مقاله HIIT, Beta vulgaris, Serotonin receptor, Dopamine receptor, Aging, Diabetes
نویسندگان مقاله | Parisa Ghanbari
Department of Sport Physiology, Behbahan Branch, Islamic Azad University, Behbehan, Iran


| Sanaz Khajehzadeh
Department of Sport Physiology, Behbahan Branch, Islamic Azad University, Behbehan, Iran


| Asieh Sayyed
Department of Sport Physiology, Behbahan Branch, Islamic Azad University, Behbehan, Iran


| Davood Raeisi
Department of Internal Medicine, Faculty of Medicine, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran


| Omidreza Salehi
Department of Physical Education and Sport Sciences, University of Kurdistan, Sanandaj, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_20895.html
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نوع مقاله منتشر شده Original Research Article
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