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Avicenna Journal of Phytomedicine، جلد ۱۲، شماره ۵، صفحات ۵۳۷-۵۴۷
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عنوان انگلیسی Curcuma reduces kidney and liver damage induced by titanium dioxide nanoparticles in male Wistar rats
چکیده انگلیسی مقاله Objective: The current study was designed to investigate the protective effects of curcuma caplet against titanium dioxide nanoparticles (nTiO2)-induced damage in liver and kidney of male Wistar rats.Materials and Methods: Thirty adult (7-8 week old) male rats (200 g) were randomly divided into 5 groups of 6 each. The first and second groups received olive oil and nTiO2 (300 mg/kg body weight) as control and nTiO2 groups, respectively. The third, fourth, and fifth groups received Curcuma at concentrations of 100, 200, and 300 mg/kg body weight in addition to 300 mg/kg body weight of nTiO2, respectively. The treatment was performed through gavage for 3 weeks. Rats' blood was examined for total antioxidant capacity (TAC), total oxidant status (TOS), and malondialdehyde (MDA) levels as well as antioxidant enzymes superoxide dismutase (SOD), and glutathione peroxidase (GPx), and activity of liver enzymes alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and renal factors (urea, uric acid, and creatinine). Histological analyses were also performed to estimate the extent of hepatic and renal injury.Results: nTiO2-induced liver and kidney damage by decreased serum SOD, GPx, and TAC (p< 0.05). Fu+rthermore, nTiO2 increased serum MDA and TOS, and renal (Creatinine, Urea and Uric acid) and liver parameters (ALT, AST, ALP and LDH) (p< 0.05). However, Curcuma treatment was able to moderate these changes dramatically (p< 0.05). The results were confirmed by histopathological data. Conclusion: This study showed the antioxidant properties of curcuma against the side effects of nTiO2.
کلیدواژه‌های انگلیسی مقاله Curcuma, Titanium dioxide nanoparticles, Toxicity, Wistar rats
نویسندگان مقاله | Mandana Shirdare
Department of Medical Laboratory, School of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran


| Fatemeh Jabbari
Department of Medical Laboratory, School of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran


| Maryam Salehzadeh
Department of Orthodontics, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran


| Nasrin Ziamajidi
Department of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran


| Alireza Nourian
Department of Pathology, School of Veterinary Medicine, Bu-Ali Sina University, Hamadan, Iran


| Shirin Heidarisasan
Department of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran


| Azar Ghavimishamekh
Department of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran


| Masoumeh Taheri Azandariani
Neurophysiology Research Center, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran


| Roghayeh Abbasalipourkabir
Department of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_20567.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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