این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Journal of Dental Materials and Techniques، جلد ۱۱، شماره ۲، صفحات ۱۲۷-۱۳۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Detection of the Release of Chlorhexidine from Cured Denture Resins Discs: Subsequently Deducing the Ability of Denture Resin as a Drug Carrier
چکیده انگلیسی مقاله Introduction: The impact of Candida-associated denture stomatitis has been vastly discussed in the literature, starting from simple routine oral hygiene practices to the use of the denture itself as a drug delivery unit. Since candidiasis tends to keep recurring, the use of antifungal drugs in the denture or liner provides the benefit of placing the patient under oral drug intake for a long period of time. This in-vitro study aimed to assess the release of chlorhexidine from the acrylic resin discs made from two resins, heat cure and light cure. The study also intended to assess the presence of the drug release and its sufficient effectiveness to be reproduced in-vivo in the treatment of oral candidiasis. Methods: Standard chlorhexidine solution, Chlorhexidine treated heat cure, and light cure resin disc soaked solutions were subjected to test under high-performance liquid chromatography (HPLC) and scanning electron microscopy for the release of chlorhexidine. Results: The HPLC analysis of heat cure resin demonstrated that the area and height of chlorhexidine release were comparable to those of the standard chlorhexidine solution. This implies the local release of chlorhexidine in-vitro. Conclusion: In this study, it was found that chlorhexidine release in heat cure discs is less when compared to the standard stock solution; nonetheless, it is good enough to reach the minimum inhibition concentration of chlorhexidine to be effective against candidiasis. Although this study was limited in nature, the results raised hope for further evaluation of dentures as a drug delivery system.
کلیدواژه‌های انگلیسی مقاله acrylic resin, candidiasis, Chlorhexidine, High-performance liquid chromatography
نویسندگان مقاله | Preethy Chandran
Department of Prosthodontics, Senior Assistant Professor,Dr.MGR University,Chennai,India


| Sabarigirinathan Chitrapulthra Pillai
Professor, Vice-Principal, Dr.MGR University,Chennai,India


| Sriramaprabu Govindasamy
Department of Prosthodontics, Associate Professor, Dr.MGR University, Chennai,India


| Sakthidevi Arumugasamy
Private practitioner, Chennai,India
نشانی اینترنتی https://jdmt.mums.ac.ir/article_20348.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات