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Nanomedicine Journal، جلد ۹، شماره ۴، صفحات ۲۹۶-۳۰۶
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عنوان انگلیسی Silver nanoparticles modulate high fat high carbohydrate diet induced metabolic changes in rats via reducing lipid peroxidation, PDGF-β and insulin resistance
چکیده انگلیسی مقاله Objective(s): Non-alcoholic fatty liver disease (NAFLD) is strongly linked with insulin resistance and type-2 diabetes through various metabolic changes. The current study was designed to investigate the modulatory effects of silver nanoparticles (AgNPs) on metabolic and inflammatory changes activated during NAFLD. Materials and Methods: Three doses of AgNPs (100, 150, and 200 μg/kg/day for 4 weeks) were tested in a high-fat high carbohydrate diet (HFHCD) induced NAFLD model in rats. Results: Sinificant (P< 0.05) improvement in dyslipidemia, hyperglycemia, and insulin levels by AgNPs was observed and more notably in the group that received 200 μg/kg/day AgNPs. Acute phase inflammatory protein C-reactive protein and monocytes chemoattractant protein-1 were significantly (P< 0.05) lowered by AgNPs. Inline, lipid peroxidation and PDGF-β levels were significantly (P< 0.05) reduced in groups that received different doses of AgNPs. Furthermore, AgNPs especially in the large dose (200 μg/kg/day) significantly decreased (P< 0.05) the measured level of the inflammatory cytokines (IL-1β, IL-6, and TNF-α) compared with the HFHCD group level.Conclusion: Collectively, results propose the ability of AgNPs to modulate metabolic changes accompa-nying NAFLD through reducing lipid peroxidation and targeting inflammatory cytokines mediating insulin resistance.
کلیدواژه‌های انگلیسی مقاله Fatty liver, insulin resistance, Nanoparticles, Silver
نویسندگان مقاله | Mahmoud Ashri
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura Egypt


| Nashwa Abu-Elsaad
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura Egypt


| Tarek Ibrahim
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura Egypt
نشانی اینترنتی https://nmj.mums.ac.ir/article_21067.html
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