| چکیده انگلیسی مقاله |
Introduction: For interpretation of the most common biochemical markers reference intervals (RIs) are widely considered and reported. Therefore, in this study, we aimed to determine age-specific RIs for some biochemical tests by removing and/or limiting critical gaps including sex, age group, geographical region, measurement device, and type of kits and reagents for routine laboratory biochemical variables in healthy adolescent girls aged 12-19 years.Materials and Methods: In this cross-sectional study a total of 1026 adolescent girl was recruited. According to the study aim, the levels of serum for some routine biochemical tests were measured on a BT-3000 auto-analyzer. On the basis of the non-parametric rank method and by use of CLSI Ep28-A3 guidelines, we determined age-specific RIs, including confidence interval 90%, under specific exclusion criteria.Results: Age partitioning was required for none of the upper and lower limits of biochemical markers. All Serum biochemical tests concentration remained relatively constant throughout the age range. Conclusion: By removing and/or limiting critical gaps involved in reference values of biochemical tests, it has provided an important understanding of metabolic processes and it has facilitated clinical application to track different diseases better |
| نویسندگان مقاله |
| Mehran Pashirzad
Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Hamideh Ghazizadeh
International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
| Mohsen Seddigh Shamsi
Department of Internal Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Mahdiyeh Yaghooti-Khorasani
International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
| Reza Assaran Darban
Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
| Atieh Kamel Khodabandeh
Social Determinants of Health Research Center, Mashhad University of Medical sciences, Mashhad, Iran.
| Ensieh Akbarpour Bahre
Social Determinants of Health Research Center, Mashhad University of Medical sciences, Mashhad, Iran.
| Maryam Mohammadi Bajgiran
International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
| Amin Mansouri
International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
| Reza Javid Dash Bayyaz
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
| Parisa Asadian
Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
| Khashayar Khanizadeh
Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.
| Hale Akhtari
Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.
| Melika Hadizadeh
Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.
| Arvin Babaei
Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.
| Sayyed Saeid Khayatzadeh
International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
| Gordon A. Ferns
Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK.
| Habibollah Esmaily
Social Determinants of Health Research Center, Mashhad University of Medical sciences, Mashhad, Iran.
| Majid Ghayour-Mobarhan
InInternational UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
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