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The Archives of Bone and Joint Surgery، جلد ۱۰، شماره ۷، صفحات ۶۰۱-۶۱۰

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عنوان انگلیسی Effects of Vitamin D3 Fortified Low-fat Dairy Products on Bone Density Measures in Adults with Abdominal Obesity: A Randomized Clinical Trial
چکیده انگلیسی مقاله Background: Bone disease-related fractures constitute a heavy burden on the healthcare systems and economy.Vitamin D is an important regulator of bone health and its deficiency is a global problem. This study aimed to evaluatethe effect of the 1,500 IU nano-encapsulated vitamin D used for fortifying low-fat dairy products (milk and yogurt) onbone health parameters.Methods: This parallel totally blinded, randomized controlled trial was part of the Ultraviolet Intake by NutritionalApproach study and conducted on 306 individuals with abdominal obesity. Individuals were randomly assigned tofour groups, including fortified low-fat milk (1,500 IU nano-encapsulated vitamin D3 per 200 g/d), non-fortified low-fatmilk, fortified low-fat yogurt (1,500 IU nano-encapsulated vitamin D3 per 150 g/d), and non-fortified low-fat yogurt,for 10 weeks between January and March 2019. Bone mineral density (BMD) and trabecular bone score (TBS) weremeasured at the baseline and end of the trial. Trabecular bone score and BMD were defined as primary and secondaryoutcomes.Results: There were no significant differences in TBS and BMD between the intervention and control groups at theend of the trial (P>0.05).Conclusion: This trial demonstrated no significant effect of nano-encapsulated vitamin D fortified milk and yogurt onBMD and TBS. There remains a need for longer-term trials regarding bone health outcomes to establish optimal dosesof fortification.Level of evidence: I
کلیدواژه‌های انگلیسی مقاله BMD, bone health, fortification, TBS, Vitamin D3

نویسندگان مقاله | Payam Sharifan
1.International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran 2 Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran 3 Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Elahe Hassanzadeh
International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran


| Maryam Mohammadi-Bajgiran
International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran


| Vahid Reza Dabbagh
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Elham Aminifar
Student Research Committee, Islamic azad University, Mashhad Branch, Mashhad, Iran


| Hamideh Ghazizadeh
International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran- Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Sara Saffar-Soflaei
International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran- Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Susan Darroudi
International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran - Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Davoud Tanbakouchi
Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Mohammad Reza Fazl-Mashhadi
Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran


| Ali Ebrahimi-Dabagh
Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran


| Mohammad Amin Mohammadi
Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran


| Anahid Hemmatpur
Department of Biochemistry, School of Medicine, Shahid Sadoughi University of Medical sciences and health Services, Yazd, Iran


| Gordon A. Ferns
Division of Medical Education, Brighton & Sussex Medical School, Falmer, Brighton, Sussex, UK


| Habibollah Esmaily
Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Ramin Sadeghi
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Majid Ghayour-Mobarhan
International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran



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