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Journal of Rehabilitation Sciences and Research، جلد ۹، شماره ۲، صفحات ۷۲-۷۸
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عنوان انگلیسی Comparison of Brain atrophic changes in dementia patients with and without swallowing dysfunction
چکیده انگلیسی مقاله Background: on the one hand, very limited studies were performed on identifying the active regions during swallowing among healthy individuals and those with dementia. On the other hand, to the best of our knowledge, no research has yet compared the injured areas in the brain of patients with dementia with and without dysphagia, such that damage to specific regions in dementia causes dysphagia may be found using this approach. The present study was performed to evaluate the atrophic changes in the internal temporal lobe (hippocampus), frontal (anterior cingulate cortex), and parietal (posterior cingulate cortex), and insula cortex in these patients.Methods: the present study is a retrospective cross-sectional study. 54 patients with dementia were investigated. The data were collected using a checklist, including information related to the dysphagia, and the brain MRI findings to determine atrophy. The extent of atrophic changes was recorded in the checklist using the median temporal lobe atrophy (MTA) score, Koedem score scale, and the global cortical atrophy (GCA) scale. To present the results, descriptive statistics, and data comparison, chi-square tests were used.Results: The mean age of the examined patients was 72.01 with a standard deviation of 10.64 years, and range of 50-95 years. Out of them, 32 (59.3%) were male, and 22 (40.7%) were female. The degree atrophy of hippocampus (p=0.12), frontal lobe (P=0.46), parietal lobe (P=0.83), and insular cortex (P=0.91) in the patients with and without dysphagia did not show significant differences. The frequency distribution of the degree of atrophy based on the site of the development of atrophy was significant in the patients with dysphagia (P=0.033).Conclusion: In general, the findings showed that individuals with dementia who had dysphagia had more hippocampal and frontal lobe (and anterior cingulate) atrophy than dementia patients who did not have this impairment.
کلیدواژه‌های انگلیسی مقاله Dementia, Swallowing Disorders, Atrophy, MRI
نویسندگان مقاله Mansoureh Chegeni |
Radiology department, Shiraz University of Medical Sciences, Shiraz Iran

Shiva Ebrahimian Dehaghani |
Speech Therapy Department, School of Rehabilitation Sciences, Shiraz University of Medical Sciences, Shiraz, Iran

Mehrzad Lotfi |
Radiology department, Shiraz University of Medical Sciences, Shiraz Iran

Zahra Salami |
Neurology department, Shiraz University of Medical science, Shiraz Iran

نشانی اینترنتی https://jrsr.sums.ac.ir/article_48306_321115d5bb45ceb22401563b204ad223.pdf
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