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Iranian Journal of Basic Medical Sciences، جلد ۲۶، شماره ۳، صفحات ۳۰۱-۳۰۷
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Aortic Ischemia-Reperfusion Injury and Potency of Fluoxetine |
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| چکیده انگلیسی مقاله |
OBJECTIVE(S): Due to cross-clamping of the aorta during aortic aneurysm surgeries, ischemia-reperfusion (IR) develops, and it may cause damage to aorta itself or even to remote organs by oxidative stress or inflammation. Fluoxetine (FLX) which might be used in the preoperative period for its tranquilizing effect also has antioxidant effects in short-term use. The purpose of our study is to examine whether FLX protects aorta tissue, against the damage caused by IR.METHODS: 3 groups of Wistar rats formed randomly. 1) Control group (sham-operated), 2) IR group (60 min. ischemia+120 min. perfusion), 3) FLX+IR group (FLX dose was 20 mg/kg for 3 days i.p. before IR). At the end of each procedure, aorta samples were collected, and oxidant-antioxidant, anti-inflammatory, and anti-apoptotic status of the aorta were evaluated. Histological examinations of the samples were provided. RESULTS: Levels of LOOH, MDA, ROS, TOS, MPO, TNFα, IL-1β, IL-6, NF-kB, MMP-9, caspase-9, 8-OHdG, NO, and HA were found to be significantly increased in the IR group compared to control (p< 0.05) and the SOD, GSH, TAS, and IL-10 levels were significantly lower (p< 0.05). FLX significantly decreased LOOH, MDA, ROS, TOS, MPO, TNFα, IL-1β, IL-6, NF-kB, MMP-9, caspase-9, 8-OHdG, NO, and HA levels in the FLX+IR group compared to IR group (p< 0.05) and increased IL-10, SOD, GSH, and TAS (p< 0.05). FLX administration prevented the deterioration of aortic tissue damage.CONCLUSION: Our study is the first study that demonstrates FLX mediated suppression of IR injury in the infrarenal abdominal aorta by antioxidant, anti-inflammatory, and anti-apoptotic properties. |
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| کلیدواژههای انگلیسی مقاله |
Fluoxetine, aorta, Reperfusion injury, Oxidative stress, Inflammation, Apoptosis, Rat |
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| نویسندگان مقاله |
| Mehmet Altan
Istanbul University-Cerrahpaşa, Cerrahpasa Medical Faculty, Department of Physiology, Istanbul, Turkey
| Muhittin Yaman
Vocational Sch. of Health Sciences, Istanbul University-Cerrahpaşa, Istanbul, Turkey
| Gulnaz Kervancioglu
Istanbul Aydın University, Medical Faculty, Department of Histology & Embryology, Istanbul, Turkey
| Aysu Kilic
Department of Physiology, Medical Faculty, Bezmialem University, Istanbul, Turkey
| Elif Kervancioglu Demirci
Istanbul University, Istanbul Faculty of Medicine, Department of Histology & Embryology, Istanbul, Turkey
| Sila Hidayet Bozdogan Polat
Istanbul University-Cerrahpaşa, Cerrahpasa Medical Faculty, Department of Physiology, Istanbul, Turkey
| Zeliha Karadeniz
Istanbul Aydın University, Medical Faculty, Department of Obstetrics & Gynecology, Istanbul, Turkey
| Ibrahim Guner
Tekirdağ Namık Kemal University, Medical Faculty, Department of Physiology, Tekirdağ, Turkey
| Nermin Yelmen
Istanbul University-Cerrahpaşa, Cerrahpasa Medical Faculty, Department of Physiology, Istanbul, Turkey
| Gulderen Sahin
Istanbul Aydın University, Medical Faculty, Department of Physiology, Istanbul, Turkey
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| نشانی اینترنتی |
https://ijbms.mums.ac.ir/article_21679.html |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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