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Iranian Journal of Basic Medical Sciences، جلد ۲۶، شماره ۱، صفحات ۲۳-۲۹
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عنوان انگلیسی Berberine hydrochloride improves cognitive deficiency through hippocampal up-regulation of neurotrophins following inhalant self-administration of methamphetamine
چکیده انگلیسی مقاله Objective(s): Chronic methamphetamine (METH) abuse is recognized as an important risk factor for cognitive impairment. A plant-based isoquinoline alkaloid, Berberine hydrochloride (BER), shows memory and cognition enhancement properties. Due to the aim of the present study which is to investigate the influence of BER administration on METH-induced cognitive deficits, we investigated neurotrophin signaling including brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) as a possible mechanism by which BER exerts its cognitive improvement influences. Materials and Methods: In this experimental study, thirty-two male Wistar rats were randomly classified into four groups, including non-treated control, intubated control, METH-inhaled, and METH-inhaled + BER-intubated. Rats in the METH-inhaled group underwent METH inhalation for 14 days, and the BER-inhaled and BER-intubated rats were intubated (100mg/kg) for the following three weeks. A novel object recognition task (NORt) was carried out on days 36 and 37. Rats were sacrificed for histological preparations after the behavioral tests. Neurotrophic factors, including GDNF and BDNF, were evaluated by immunofluorescence staining in the hippocampus. Results: This experiment indicated a dramatic improvement in cognitive deficits associated with chronic METH abuse (P< 0.001). Furthermore, a significant decrease in the expression of both neurotrophins, GDNF (P< 0.001) and BDNF (P< 0.001), was observed in the METH-inhaled group compared with the METH-inhaled group treated with BER and non-treated control group. Conclusion: Activation of neurotrophic factors after BER administration resulted in improvement of METH-induced cognitive deficits. Therefore, BER may be considered a promising treatment for METH users who experience cognition deficits.
کلیدواژه‌های انگلیسی مقاله Addiction, Cognition, substance abuse, Neurotrophic factors, Neuroprotective
نویسندگان مقاله | Fahime Mohseni
Center for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Iran


| Raheleh Rafaiee
Department of Neuroscience, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran


| Leila Rezaeian
Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran


| Mohammad Niroumand Sarvandani
Addiction Research Center, Shahroud University of Medical Sciences, Shahroud, Iran


| Hamid Kalalian Moghadam
Department of Addiction Studies, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_21310.html
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