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Iranian Journal of Basic Medical Sciences، جلد ۲۵، شماره ۱۰، صفحات ۱۱۷۷-۱۱۸۲
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عنوان انگلیسی Does insular cortex lesion cause tinnitus in rats?
چکیده انگلیسی مقاله Objective(s): Tinnitus is defined as ringing of the ears that is experienced when there is no external sound source, and is an auditory phantom sensation. The insula as a multimodal cortex has been shown to be involved in the processing of auditory stimuli rather than other sensory and motor processing and reported to correlate with some aspects of tinnitus. However, its exact role is not clear. The present study aimed to investigate the effect of excitotoxic lesions limited to the insular cortex on the ability to detect a gap in background noise.Materials and Methods: Gap detection test and prepulse inhibition, two objective measurements of auditory startle response, were measured, in 33 male Wistar rats, before and up to four weeks after insular lesion in three experimental groups (sham, control, and lesion). Results: The ability to detect the gap interposed between 60dB background noise was impaired at weeks 2, 3, and 4 following insular lesion, while prepulse inhibition remained intact up to four weeks after surgery.Conclusion: These findings indicated that excitotoxic lesions of the insular cortex may produce a tinnitus-like phenomenon in rats while sparing the hearing sensitivity; suggesting that the insular cortex may have a role in the development of tinnitus.
کلیدواژه‌های انگلیسی مقاله Insular cortex, Prepulse inhibition, Rats, Startle reflex, Tinnitus
نویسندگان مقاله | Minoo Karimi
Department of Audiology, School of Rehabilitation, Tehran University of Medical Science, Tehran, Iran


| Saeid Farahani
Department of Audiology, School of Rehabilitation, Tehran University of Medical Science, Tehran, Iran


| Farinaz Nasirinezhad
Physiology Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran| Department of Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Shohreh Jalaei
Department of Physiotherapy, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran


| Helnaz Mokrian
Department of Audiology, School of Rehabilitation, Tehran University of Medical Science, Tehran, Iran


| Ali Shahbazi
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran|Department of Neuroscience, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_20930.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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