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Iranian Journal of Basic Medical Sciences، جلد ۲۵، شماره ۹، صفحات ۱۰۸۴-۱۰۹۰
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عنوان انگلیسی Cross talk of vasopressin conditioned cell therapy in ischemic heart disease: Role of oxidative stress markers
چکیده انگلیسی مقاله Objective(s): Background: Impaired coronary blood flow causes cardiac ischemia. Cellular therapy is a new approach to the treatment of myocardial ischemia. This study aimed to investigate the effect of adipose tissue-derived mesenchymal stem cells (AD-MSCs) conditioned with vasopressin on oxidative stress, perivascular collagen, and angiogenesis caused by myocardial infarction (MI) in rats. Materials and Methods: We divided 40 male albino Wistar rats into 4 groups; Control group; No intervention; in experimental groups, after it generated induced MI on models, it divided into three groups: Vehicle group (150 μl of cell-free culture medium received); ASC-MI group (6× 106 AD-MSC received) and AVP-ASC-MI group (received 6 × 106 AD-MSC conditioned with 10 nM vasopressin). Then, histologic parameters and anti-oxidant enzymes were evaluated 7 days post-MI cell injection. Results: Arterial muscle diameter improved and collagen deposition around the coronary arteries decreased in cell-received groups compared with the vehicle group. Malondialdehyde (MDA), catalase (CAT), (GSH) Glutathione, and Total Anti-oxidant Capacity (TAC) parameters were not significantly different between the cells received groups compared with the vehicle group. But the Catalase (CAT) parameter in the ASC-MI group had a significant increase from the control group. Conclusion: We prepared direct evidence that intramyocardial injection of AD-MSCs reveals the positive cardiac remodeling post-MI in rats, and these useful effects can be more enhanced by administrating injection of conditioned ADSCs with vasopressin.
کلیدواژه‌های انگلیسی مقاله Anti-Oxidants, Catalase, Coronary vessels, Glutathione, Malondialdehyde, Mesenchymal stem cells, Myocardial infarction, Myocardial schemia Oxidative stress, Vasopressins
نویسندگان مقاله | Mona Bagheri
Student Research Committee, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran


| Shakiba Nasiri Boroujeni
Student Research Committee, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran


| Hassan Ahmadvand
Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran


| Afshin Nazari
Razi Herbal Medicines Research Center, Department of Physiology, Lorestan University of Medical Science, Khorramabad, Iran|Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khorramabad, Iran


| farzaneh Chehelcheraghi
Department of Anatomical Sciences, School of Medicine Lorestan University of Medical Sciences, Khorramabad, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_20928.html
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