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Iranian Journal of Basic Medical Sciences، جلد ۲۵، شماره ۸، صفحات ۹۳۴-۹۴۶
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عنوان انگلیسی Lactobacilli and Bifidobacterium as anti- atherosclerotic agents
چکیده انگلیسی مقاله Atherosclerosis is the thickening or hardening of the arteries which is caused by a buildup of atheromatous plaque in the inner lining of an artery. Hypercholesterolemia, inflammation, oxidative stress, and trimethylamine N-oxide (TMAO) are important risk factors for atherosclerosis. Therefore, this study aimed to review the anti-atherosclerotic effects of Lactobacilli and Bifidobacterium via improving lipid profile and reducing the effects of oxidative stress, inflammation, and TMAO. To prepare the present review, several databases such as Scopus, PubMed, and Google Scholar were searched, and relevant articles from 1990 until 2022 were selected and reviewed. The present review showed that Lactobacilli and Bifidobacterium reduce the risk of atherosclerosis in both in vitro and in vivo studies by breaking down or altering cholesterol metabolism with the help of their by-products and by reducing inflammation and oxidative stress and TMAO. Consumption of Lactobacilli and Bifidobacterium can be useful in prevention of atherosclerosis.
کلیدواژه‌های انگلیسی مقاله Atherosclerosis, Bifidobacterium, Hypercholesterolemia, Inflammation, Lactobacilli, Oxidative stress, TMAO
نویسندگان مقاله | Milad Abdi
Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran


| Hadi Esmaeili Gouvarchin Ghaleh
Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran


| Reza Ranjbar
Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_20668.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Review Article
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