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Iranian Journal of Basic Medical Sciences، جلد ۲۵، شماره ۸، صفحات ۹۵۴-۹۶۳
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عنوان انگلیسی Protective effect of protein hydrolysates from Litopenaeus vannamei waste on oxidative status, glucose regulation, and autophagy genes in non-alcoholic fatty liver disease in Wistar rats
چکیده انگلیسی مقاله Objective(s): The effects of protein hydrolysates (FP) from Litopenaeus vannamei on oxidative stress, and autophagy gene expression was investigated in the NAFLD-induced rats. Materials and Methods: For this purpose, twenty-four male rats were divided into four groups: Control, High-fat diet (HFD), FP20+HFD, and FP300+HFD (20 and 300 mg FP /kg rat body weight) and fed for 70 days. Results: The results indicated that the rat body and relative weight of the liver were not affected by experimental treatments (P>0.05) although the highest relative weight of the liver was observed in HFD treatment. The highest and lowest values for antioxidant enzymes and MDA concentration were observed in FP treatments (P< 0.05). Also, the results showed that FP significantly decreased liver enzymes (ALT, AST) in the liver in comparison with HFD treatment (P< 0.05). Plasma biochemical indices were investigated and the lowest amylase, ALP, fasting glucose, insulin, HOMA-IR, triglycerides, cholesterol, and inflammation cytokines (TNF-α, IL-6) were seen in the FP treatments which had a significant difference with HFD (P< 0.05). Autophagy gene expression in the liver cells was affected by experimental diets and the lowest expression of Beclin-1 and Atg7 was observed in HFD and FP300 treatments. Interestingly, the highest expression of LC3-ɪ and P62 was seen in HFD and FP treatments, not in the control. Conclusion: Overall, the results of this experiment indicated that FPs extracted from Whiteleg shrimp at 50 °C improve the oxidative status, glucose metabolism, and autophagy gene expression and could be used as a useful nutritional strategy in fatty liver prevention.
کلیدواژه‌های انگلیسی مقاله Autophagy, Bioactive peptides, Fatty liver, Insulin, Oxidative Enzymes, Whiteleg shrimp
نویسندگان مقاله | Mirhossein Hadavi
Department of Biology, Faculty of Science, Urmia University, Urmia, Iran


| Ebrahim H. Najdegerami
Department of Biology, Faculty of Science, Urmia University, Urmia, Iran


| Mehdi Nikoo
Department of Pathobiology and Quality Control, Artemia & Aquaculture Research institute, Urmia University, Urmia, Iran


| Vahid Nejati
Department of Biology, Faculty of Science, Urmia University, Urmia, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_20781.html
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